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Kidney tissue immunity in 2023

Single-cell genomics sheds light on kidney tissue immunity

Nature Reviews Nephrology volume 20, pages 71–72 (2024)Cite this article

Subjects

The widespread availability of single-cell and single-nuclear genomic tools has enabled unbiased and high-dimensional assessment of tissue immunity in the kidney. The application of these technologies to human and mouse kidney samples, combined with spatial transcriptomics, has yielded unexpected insights into how resident and infiltrating immune cells maintain tissue homeostasis and drive disease.

Key advances

  • Large-scale single-cell and single-nucleus RNA sequencing datasets of human kidney samples provide a rich community resource that can generate hypotheses and reveal potential treatment targets for validation and/or further investigation.

  • The kidney is home to tissue-resident B cells in homeostasis that polarize local macrophages to an anti-inflammatory phenotype via IL-10 secretion.

  • Ageing kidneys contain lymphocyte aggregates (tertiary lymphoid structures) adjacent to damaged proximal tubules; these lymphocytes produce cytokines that can sustain and amplify local inflammation.

  • In anti-neutrophil cytoplasmic antibody-associated vasculitis, CD4 T cells in the kidney produce granulocyte–macrophage colony-stimulating factor, stimulating macrophage production of metalloproteinase 12, which has the potential to damage basement membrane components.

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Fig. 1: Tissue immunity in the kidney in health and disease.

References

  1. Lake, B. B. et al. An atlas of healthy and injured cell states and niches in the human kidney. Nature 619, 585–594 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Stewart, B. J. et al. Spatiotemporal immune zonation of the human kidney. Science 365, 1461–1466 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hansen, J. et al. A reference tissue atlas for the human kidney. Sci. Adv. 8, eabn4965 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yoshikawa, T. et al. Tertiary lymphoid tissues are microenvironments with intensive interactions between immune cells and proinflammatory parenchymal cells in aged kidneys. J. Am. Soc. Nephrol. 34, 1687–1708 (2023).

    Article  PubMed  Google Scholar 

  5. Suchanek, O. et al. Tissue-resident B cells orchestrate macrophage polarisation and function. Nat. Commun. 14, 7081 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Paust, H. J. et al. CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12. Sci. Transl. Med. 15, eadd6137 (2023).

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Cambridge Institute for Therapeutic Immunology and Infectious Diseases and Molecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK

    Andrew P. Stewart & Menna R. Clatworthy

  2. Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK

    Menna R. Clatworthy

Authors
  1. Andrew P. Stewart
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  2. Menna R. Clatworthy
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Correspondence to Menna R. Clatworthy.

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The authors declare no competing interests.

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Stewart, A.P., Clatworthy, M.R. Single-cell genomics sheds light on kidney tissue immunity. Nat Rev Nephrol 20, 71–72 (2024). https://doi.org/10.1038/s41581-023-00802-0

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