Genome-wide sequencing (GWS) is the most sensitive test available for detecting pathogenic genetic variants. In line with guidelines in North America and Europe, best clinical practice requires GWS to be implemented as a holistic clinical service that includes both pre-test and post-test genetic counselling.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Toward the diagnosis of rare childhood genetic diseases: what do parents value most?
European Journal of Human Genetics Open Access 26 April 2021
-
Germline susceptibility variants impact clinical outcome and therapeutic strategies for stage III colorectal cancer
Scientific Reports Open Access 08 March 2019
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wright, C. F., FitzPatrick, D. R. & Firth, H. V. Paediatric genomics: diagnosing rare disease in children. Nat. Rev. Genet. 19, 253–268 (2018).
Patch, P. & Middleton, A. Genetic counselling in the era of genomic medicine. Br. Med. Bull. 126, 27–36 (2018).
Knoppers, B., Zawati, M. & Senecal, K. Return of genetic testing results in the era of whole-genome sequencing. Nat. Rev. Genet. 16, 553–559 (2015).
Christie, J. et al. Cognitive and psychological impact of BRCA genetic counseling in before and after definitive surgery breast cancer patients. Ann. Surg. Oncol. 19, 4003–4011 (2012).
Armstrong, J. et al. Utilization and outcomes of BRCA genetic testing and counseling in a national commercially insured population. JAMA Oncol. 1, 1251–1260 (2015).
Kurian, A. W. et al. Genetic testing and counseling among patients with newly diagnosed breast cancer. JAMA 317, 531–534 (2017).
Author information
Authors and Affiliations
Contributions
A.M.E. contributed to all aspects of the article. J.M.F. made substantial contributions to discussions of the content and reviewed and/or edited the manuscript before submission.
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Elliott, A.M., Friedman, J.M. The importance of genetic counselling in genome-wide sequencing. Nat Rev Genet 19, 735–736 (2018). https://doi.org/10.1038/s41576-018-0057-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41576-018-0057-3
This article is cited by
-
The genetics of cardiac amyloidosis
Heart Failure Reviews (2022)
-
Toward the diagnosis of rare childhood genetic diseases: what do parents value most?
European Journal of Human Genetics (2021)
-
Normalising life at risk of Huntington’s disease. A qualitative study of backgrounds and coping strategies of fears of genetic discrimination
European Journal of Human Genetics (2021)
-
Consent for rapid genomic sequencing for critically ill children: legal and ethical issues
Monash Bioethics Review (2021)
-
Dying to see you? Deaths on a clinical genetics waiting list in the Republic of Ireland; what are the consequences?
Journal of Community Genetics (2021)