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BREAST CANCER

Triple-negative breast cancers — a panoply of cancer types

Nature Reviews Clinical Oncology volume 15, pages 347–348 (2018)Cite this article

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The biological complexity of triple-negative breast cancers (TNBCs) and the lack of highly recurrent targetable genetic alterations pose major challenges for the implementation of targeted therapies for this disease. A recent multiomic in silico study has identified genetic drivers of five different TNBC molecular subtypes, providing new opportunities for precision medicine approaches.

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Acknowledgements

The authors are grateful to A. Li and B. Weigelt of the Memorial Sloan Kettering Cancer Center, New York, NY, USA, for their scientific input and critical reading of the manuscript.

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Authors and Affiliations

  1. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Fresia Pareja & Jorge S. Reis-Filho

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  1. Fresia Pareja
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  2. Jorge S. Reis-Filho
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Correspondence to Jorge S. Reis-Filho.

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The authors declare no competing interests.

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RELATED LINKS

TNBCtype online subtyping tool: https://cbc.mc.vanderbilt.edu/tnbc/

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Pareja, F., Reis-Filho, J.S. Triple-negative breast cancers — a panoply of cancer types. Nat Rev Clin Oncol 15, 347–348 (2018). https://doi.org/10.1038/s41571-018-0001-7

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