Tumour biomarkers

Definition

Tumour biomarkers is a term used to describe many different potential markers of cancer development and progression. These markers can come in many forms – for example, proteins, biochemicals, DNA and RNA – and ideally they should be specific to a particular type of cancer and not present in normal tissues or in healthy individuals.

Latest Research and Reviews

  • Research | | open

    In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.

    • Julia F. Hopkins
    • , Veronica Y. Sabelnykova
    • , Joachim Weischenfeldt
    • , Ronald Simon
    • , Jennifer A. Aguiar
    • , Rached Alkallas
    • , Lawrence E. Heisler
    • , Junyan Zhang
    • , John D. Watson
    • , Melvin L. K. Chua
    • , Michael Fraser
    • , Francesco Favero
    • , Chris Lawerenz
    • , Christoph Plass
    • , Guido Sauter
    • , John D. McPherson
    • , Theodorus Kwast
    • , Jan Korbel
    • , Thorsten Schlomm
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Research |

    A silent single-nucleotide variant (SNV) affecting the transcription of a long noncoding RNA (lncRNA EGFR-AS1) within the EGFR coding region alters the EGFR isoform ratio and modulates oncogene addiction and response to EGFR tyrosine kinase inhibitors in squamous-cell cancers. Proof-of-concept validation in patients supports the notion that this SNV and levels of the lncRNA could be used to predict response to therapy in a clinical setting. These results, together with findings by Bal et al., uncover the functional role of noncoding RNAs in modulating the response to targeted therapies in cancer.

    • Daniel S W Tan
    • , Fui Teen Chong
    • , Hui Sun Leong
    • , Shen Yon Toh
    • , Dawn P Lau
    • , Xue Lin Kwang
    • , Xiaoqian Zhang
    • , Gopinath M Sundaram
    • , Gek San Tan
    • , Mei Mei Chang
    • , Boon Tin Chua
    • , Wan Teck Lim
    • , Eng Huat Tan
    • , Mei Kim Ang
    • , Tony K H Lim
    • , Prabha Sampath
    • , Balram Chowbay
    • , Anders J Skanderup
    • , Ramanuj DasGupta
    •  & N Gopalakrishna Iyer
  • Reviews | | open

    Based on a consensus conference of experts in the evolution and ecology of cancer, this article proposes a framework for classifying tumours that includes four evolutionary and ecological processes: neoplastic cell diversity and changes over time in that diversity, hazards to cell survival and available resources.

    • Carlo C. Maley
    • , Athena Aktipis
    • , Trevor A. Graham
    • , Andrea Sottoriva
    • , Amy M. Boddy
    • , Michalina Janiszewska
    • , Ariosto S. Silva
    • , Marco Gerlinger
    • , Yinyin Yuan
    • , Kenneth J. Pienta
    • , Karen S. Anderson
    • , Robert Gatenby
    • , Charles Swanton
    • , David Posada
    • , Chung-I Wu
    • , Joshua D. Schiffman
    • , E. Shelley Hwang
    • , Kornelia Polyak
    • , Alexander R. A. Anderson
    • , Joel S. Brown
    • , Mel Greaves
    •  & Darryl Shibata

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