Moderate therapeutic hypothermia (33 °C during the first 24 h) in patients with coma who have been resuscitated from cardiac arrest with a nonshockable rhythm significantly improves survival with favourable neurological outcomes at day 90 compared with targeted normothermia. This finding comes from the HYPERION trial, an open-label, randomized, controlled trial that included 581 patients admitted to the intensive care unit with nonshockable cardiac arrest owing to cardiac or noncardiac causes. At day 90, patients who received moderate-hypothermia management had higher survival with a favourable neurological outcome (defined as Cerebral Performance Category score 1 or 2) than those who received targeted normothermia (10.2% versus 5.7%, P = 0.04). No differences were observed between the two groups for mortality at 90 days or the incidence of adverse events.
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Lascarrou, J.-B. et al. Targeted temperature management for cardiac arrest with nonshockable rhythm. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa1906661 (2019)
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Fernández-Ruiz, I. Hypothermia helps in nonshockable cardiac arrest. Nat Rev Cardiol 17, 6 (2020). https://doi.org/10.1038/s41569-019-0301-3
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DOI: https://doi.org/10.1038/s41569-019-0301-3