Arrhythmias

Definition

Arrhythmias are conditions in which electrical impulses are abnormally conducted through the heart, resulting in an altered heart beat – muscle contraction – rhythm. These alterations to heart beat rhythm can include changes in heart rate, irregularity of heart beats, or fibrillation of the heart muscle.

Latest Research and Reviews

  • Reviews |

    The identification of mutations in ion channels has been crucial to understanding the pathogenesis of cardiac arrhythmias, but the aetiology of a considerable number of arrhythmogenic disorders remains unknown. In this Review, Lazzerini and colleagues discuss the role of autoimmunity in the pathogenesis of cardiac arrhythmias, describing how different autoantibodies against ion channels in the heart participate in the development of these conditions.

    • Pietro Enea Lazzerini
    • , Pier Leopoldo Capecchi
    • , Franco Laghi-Pasini
    •  & Mohamed Boutjdir
  • Research |

    Patrick Ellinor and colleagues report meta-analyses of common and rare variant association studies for atrial fibrillation across multiple populations. They identify 12 new loci, some of which implicate genes in atrial electrical and mechanical function.

    • Ingrid E Christophersen
    • , Michiel Rienstra
    • , Carolina Roselli
    • , Xiaoyan Yin
    • , Bastiaan Geelhoed
    • , John Barnard
    • , Honghuang Lin
    • , Dan E Arking
    • , Albert V Smith
    • , Christine M Albert
    • , Mark Chaffin
    • , Nathan R Tucker
    • , Molong Li
    • , Derek Klarin
    • , Nathan A Bihlmeyer
    • , Siew-Kee Low
    • , Peter E Weeke
    • , Martina Müller-Nurasyid
    • , J Gustav Smith
    • , Jennifer A Brody
    • , Maartje N Niemeijer
    • , Marcus Dörr
    • , Stella Trompet
    • , Jennifer Huffman
    • , Stefan Gustafsson
    • , Claudia Schurmann
    • , Marcus E Kleber
    • , Leo-Pekka Lyytikäinen
    • , Ilkka Seppälä
    • , Rainer Malik
    • , Andrea R V R Horimoto
    • , Marco Perez
    • , Juha Sinisalo
    • , Stefanie Aeschbacher
    • , Sébastien Thériault
    • , Jie Yao
    • , Farid Radmanesh
    • , Stefan Weiss
    • , Alexander Teumer
    • , Seung Hoan Choi
    • , Lu-Chen Weng
    • , Sebastian Clauss
    • , Rajat Deo
    • , Daniel J Rader
    • , Svati H Shah
    • , Albert Sun
    • , Jemma C Hopewell
    • , Stephanie Debette
    • , Ganesh Chauhan
    • , Qiong Yang
    • , Bradford B Worrall
    • , Guillaume Paré
    • , Yoichiro Kamatani
    • , Yanick P Hagemeijer
    • , Niek Verweij
    • , Joylene E Siland
    • , Michiaki Kubo
    • , Jonathan D Smith
    • , David R Van Wagoner
    • , Joshua C Bis
    • , Siegfried Perz
    • , Bruce M Psaty
    • , Paul M Ridker
    • , Jared W Magnani
    • , Tamara B Harris
    • , Lenore J Launer
    • , M Benjamin Shoemaker
    • , Sandosh Padmanabhan
    • , Jeffrey Haessler
    • , Traci M Bartz
    • , Melanie Waldenberger
    • , Peter Lichtner
    • , Marina Arendt
    • , Jose E Krieger
    • , Mika Kähönen
    • , Lorenz Risch
    • , Alfredo J Mansur
    • , Annette Peters
    • , Blair H Smith
    • , Lars Lind
    • , Stuart A Scott
    • , Yingchang Lu
    • , Erwin B Bottinger
    • , Jussi Hernesniemi
    • , Cecilia M Lindgren
    • , Jorge A Wong
    • , Jie Huang
    • , Markku Eskola
    • , Andrew P Morris
    • , Ian Ford
    • , Alex P Reiner
    • , Graciela Delgado
    • , Lin Y Chen
    • , Yii-Der Ida Chen
    • , Roopinder K Sandhu
    • , Man Li
    • , Eric Boerwinkle
    • , Lewin Eisele
    • , Lars Lannfelt
    • , Natalia Rost
    • , Marja-Liisa Lokki
    • , Jonathan Rosand
    • , Caroline Hayward
    • , Nona Sotoodehnia
    • , Christopher D Anderson
    • , Stefan Kääb
    • , Efthymia Vlachopoulou
    • , Paul L Huang
    • , METASTROKE Consortium of the ISGC
    • , Steven A Lubitz
    • , Stefanie Heilmann-Heimbach
    • , the AFGen Consortium
    • , Emelia J Benjamin
    • , Daniel I Chasman
    • , Henry J Lin
    • , Karl-Heinz Jöckel
    • , Patrick T Ellinor
    • , Andre G Uitterlinden
    • , J Wouter Jukema
    • , Susan R Heckbert
    • , Kjell Nikus
    • , Lynne J Hocking
    • , Ruth J F Loos
    • , Alvaro Alonso
    • , David Conen
    • , Neurology Working Group of the CHARGE Consortium
    • , Moritz F Sinner
    • , Peter W Macfarlane
    • , Jennifer Kriebel
    • , Martin Dichgans
    • , Joshua C Denny
    • , Charles Kooperberg
    • , Kent D Taylor
    • , Jan Heeringa
    • , Patrik K Magnusson
    • , Sekar Kathiresan
    • , Olle Melander
    • , Jerome I Rotter
    • , Oscar H Franco
    • , Pim van der Harst
    • , Dan M Roden
    • , Stephan B Felix
    • , Mina K Chung
    • , Kathryn L Lunetta
    • , Peter Almgren
    • , Elsayed Z Soliman
    • , Christian Shaffer
    • , Archie Campbell
    • , Marju Orho-Melander
    • , Winfried März
    • , Dawood Darbar
    • , Jari Laurikka
    • , Nancy L Pedersen
    • , Albert Hofman
    • , Alexandre Pereira
    • , Uwe Völker
    • , Toshihiro Tanaka
    • , David Porteous
    • , Anders Hamsten
    • , Xiuqing Guo
    • , Bruno H Stricker
    • , Vilmundur Gudnason
    • , Erik Ingelsson
    • , Terho Lehtimäki
    •  & Christopher Newton-Cheh
    Nature Genetics 49, 946–952
  • Research |

    Kaoru Ito, Yoichiro Kamatani, Toshihiro Tanaka and colleagues report a genome-wide association study for atrial fibrillation in the Japanese population. They identify six new loci, five of which are not associated with atrial fibrillation in individuals of European ancestry, suggesting that they may be specific to the Japanese population.

    • Siew-Kee Low
    • , Atsushi Takahashi
    • , Yusuke Ebana
    • , Kouichi Ozaki
    • , Ingrid E Christophersen
    • , Patrick T Ellinor
    • , AFGen Consortium
    • , Soichi Ogishima
    • , Masayuki Yamamoto
    • , Mamoru Satoh
    • , Makoto Sasaki
    • , Taiki Yamaji
    • , Motoki Iwasaki
    • , Shoichiro Tsugane
    • , Keitaro Tanaka
    • , Mariko Naito
    • , Kenji Wakai
    • , Hideo Tanaka
    • , Tetsushi Furukawa
    • , Michiaki Kubo
    • , Kaoru Ito
    • , Yoichiro Kamatani
    •  & Toshihiro Tanaka
    Nature Genetics 49, 953–958
  • Reviews |

    Spiral-wave generators, or 'rotors', have been identified by advanced mapping methods in experimental and clinical atrial fibrillation (AF). In this Review, Nattel and colleagues describe the concepts of phase mapping and spiral-wave rotors, and summarize the ways in which rotor sources might be involved in AF maintenance. They also consider the relevance of spiral-wave rotors to the management of patients with AF.

    • Stanley Nattel
    • , Feng Xiong
    •  & Martin Aguilar

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