Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HOST RESPONSE

Going beyond gamma for TB protection

The discovery of CD153 as a novel driver of T-cell-mediated host defence against Mycobacterium tuberculosis infection advances our understanding of the requirements for protective immunity. Future investigation of CD153 as a potential correlate of tuberculosis immunity could open new avenues for vaccine design.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: CD153 expression by CD4 T cells is required for pulmonary Mtb control.

References

  1. Flynn, J. L. et al. J. Exp. Med. 178, 2249–2254 (1993).

    Article  CAS  Google Scholar 

  2. Casanova, J. L. & Abel, L. Annu. Rev. Immunol. 20, 581–620 (2002).

    Article  CAS  Google Scholar 

  3. Green, A. M., Difazio, R. & Flynn, J. L. J. Immunol. 190, 270–277 (2013).

    Article  CAS  Google Scholar 

  4. Tameris, M. D. et al. Lancet 381, 1021–1028 (2013).

    Article  CAS  Google Scholar 

  5. Sakai, S. et al. PLoS Pathog. 12, e1005667 (2016).

    Article  Google Scholar 

  6. Sallin, M. A. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0231-6 (2018).

    Article  PubMed  Google Scholar 

  7. Moguche, A. O. et al. J. Exp. Med. 212, 715–728 (2015).

    Article  CAS  Google Scholar 

  8. Sakai, S. et al. J. Immunol. 192, 2965–2969 (2014).

    Article  CAS  Google Scholar 

  9. Sun, X. et al. J. Immunol. 185, 2222–2230 (2010).

    Article  CAS  Google Scholar 

  10. Buchan, S. L. & Al-Shamkhani, A. PLoS ONE 7, e45244 (2012).

    Article  CAS  Google Scholar 

  11. Andreesen, R., Brugger, W., Lohr, G. W. & Bross, K. J. Am. J. Pathol. 134, 187–192 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Srivastava, S. & Ernst, J. D. J. Immunol. 191, 1016–1020 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kevin B. Urdahl.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cohen, S.B., Urdahl, K.B. Going beyond gamma for TB protection. Nat Microbiol 3, 1194–1195 (2018). https://doi.org/10.1038/s41564-018-0266-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-018-0266-8

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology