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BACTERIAL PATHOGENESIS

More than merely drug resistance

Nature Microbiologyvolume 3pages10781079 (2018) | Download Citation

The H445Y mutation in the β-subunit of RNA polymerase in Mycobacterium tuberculosis causes resistance to the antibiotic rifampicin and changes mycobacterial lipid composition. Infection with rpoB H445Y results in metabolic shifts that allow the bacteria to bypass a key host inflammatory response.

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Author information

Affiliations

  1. Centre for Global Health and Infectious Diseases, Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases, Tsinghua University School of Medicine, Beijing, China

    • Yu-Xiang Chen
    •  & Babak Javid

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Babak Javid.

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DOI

https://doi.org/10.1038/s41564-018-0250-3

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