News and Views

GENOME EDITING

Nanoparticles for CRISPR–Cas9 delivery

The DNA mutation that causes Duchenne muscular dystrophy in mice can be corrected, with minimal off-target effects, by gold nanoparticles carrying the CRISPR components.

  • Subscribe to Nature Biomedical Engineering for full access:

    $99

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    Hsu, P.  D., Lander, E.  S. & Zhang, F. Cell 157, 1262–1278 (2014).

  2. 2.

    Doudna, J.  A. & Charpentier, E. Science 346, 1258096 (2014).

  3. 3.

    Tabebordbar, M. et al. Science 351, 407–411 (2016).

  4. 4.

    Nelson, C.  E. et al. Science 351, 403–407 (2016).

  5. 5.

    Long, C. et al. Science 351, 400–403 (2016).

  6. 6.

    Lee, K. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-017-0137-2 (2017).

  7. 7.

    Ramadasan-Nair, R. et al. J. Biol. Chem. 289, 485–509 (2014).

  8. 8.

    Wang, M., Glass, Z.  A. & Xu, Q. Gene Ther. 24, 144–150 (2017).

  9. 9.

    Wang, H.-X. et al. Chem. Rev. 117, 9874–9906 (2017).

  10. 10.

    Yin, H., Kauffman, K.  J. & Anderson, D.  G. Nat. Rev. Drug Discov. 16, 387–399 (2017).

  11. 11.

    Staahl, B.  T. et al. Nat. Biotechnol. 35, 431–434 (2017).

  12. 12.

    Zuris, J.  A. et al. Nat. Biotechnol. 33, 73–80 (2015).

  13. 13.

    Wang, M. et al. Proc. Natl Acad. Sci. USA 113, 2868–2873 (2016).

  14. 14.

    Ran, F. A. et al. Nat. Protoc 8, 2281–2308 (2013).

Download references

Author information

Affiliations

  1. Department of Biomedical Engineering, Tufts University, Medford, MA, USA

    • Zachary Glass
    • , Yamin Li
    •  & Qiaobing Xu

Authors

  1. Search for Zachary Glass in:

  2. Search for Yamin Li in:

  3. Search for Qiaobing Xu in:

Corresponding author

Correspondence to Qiaobing Xu.