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Adipose-derived stem cells: an upcoming novel therapeutic in the management of Erectile dysfunction post radical prostatectomy in prostate cancer patients

International Journal of Impotence Research (2024)Cite this article

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Globally, prostate cancer (PC) is one of the most prevalent cancers and ranks as the fourth most diagnosed cancer in men. In 2020 alone, over 1.4 million individuals were diagnosed with PC. Contrary to popular perceptions associating PC with men aged 65 years or older, recent statistics underscore that over 10% of recent diagnoses in the United States are in men aged <55 years [1]. Although most men with early onset PC are diagnosed with low-risk diseases, the trajectory of their life expectancy is greatly influenced by prolonged side effects from treatment, poor quality of life (QoL) after treatment, and a protracted vulnerability to relapse and disease progression, which may even be fatal [2].

Definitive treatment modalities for localized PC include cryotherapy, hormone therapy, radiation therapy, and radical prostatectomy (RP). Nevertheless, each of these interventions is ridden by limitations, ultimately affecting the QoL of the patient. The choice of treatment depends on a slew of variables including disease severity, patient preferences, comorbidities, and age.

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The data in this Perspective article is not sensitive in nature and is accessible in the public domain. The data is therefore available and not of a confidential nature. All the necessary data has already been included in the manuscript.

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Acknowledgements

We acknowledge the expertise and clinical support extended by Dr. Jainam Karsiya (RiverRoute Creative Group, India) in the curation of this article.

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Author notes

  1. These authors contributed equally: Gargi Digholkar, Ryan Varghese.

Authors and Affiliations

  1. Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune, Maharashtra, 411038, India

    Gargi Digholkar & Ryan Varghese

  2. Advanced Centre for Treatment, Research, and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra, 410210, India

    Ryan Varghese & Kavita Pal

  3. Homi Bhabha National Institute, Anushakti Nagar, Mumbai, Maharashtra, 400094, India

    Ryan Varghese & Kavita Pal

  4. Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Saint Joseph’s University, Philadelphia, PA, 19104, USA

    Ryan Varghese

  5. Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India

    Rohit Sharma

Authors
  1. Gargi Digholkar
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  2. Ryan Varghese
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Contributions

Gargi Digholkar: Data curation, Writing - original draft; Ryan Varghese: Conceptualization, Data curation, Writing - original draft; Kavita Pal and Rohit Sharma: Writing – review and editing, Supervision, Resources, Project Administration; All authors commented on subsequent revisions and provided references.

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Correspondence to Kavita Pal or Rohit Sharma.

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Digholkar, G., Varghese, R., Pal, K. et al. Adipose-derived stem cells: an upcoming novel therapeutic in the management of Erectile dysfunction post radical prostatectomy in prostate cancer patients. Int J Impot Res (2024). https://doi.org/10.1038/s41443-024-00866-x

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