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Application value of serum S100B combined with glucose metabolism indexes in predicting adverse pregnancy outcomes of patients with severe preeclampsia

Journal of Human Hypertension volume 38, pages 232–237 (2024)Cite this article

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Abstract

S100 calcium-binding protein B (S100B) and glucose control are reflective of maternal-fetal risks. We investigated the value of serum S100B combined with fasting blood glucose (FBG)/hemoglobin A1c (HbA1c) in evaluating the pregnancy outcomes of patients with severe preeclampsia (SPE). The clinical characteristics of SPE patients/controls were collected. FBG/HbA1c and serum S100B levels were measured, with their correlations analyzed. SPE patients were subdivided into adverse/non-adverse outcome groups based on follow-up results. The value of different indexes in predicting pregnancy outcomes was analyzed. SPE patients showed higher systolic blood pressure, diastolic blood pressure, urine protein, and body mass index and lower platelets, gestational age at delivery, and infant birth weight than healthy controls. FBG and HbA1c were positively correlated with serum S100B. SPE patients with adverse outcomes exhibited increased serum S100B and FBG/HbA1c levels. The area under the curve of serum S100B + FBG/HbA1c in evaluating adverse pregnancy outcomes of SPE patients was 0.8412 (77.05% sensitivity/84.21% specificity), higher than either alone. Serum S100B and FBG/HbA1c were independent risk factors for adverse outcomes of SPE patients. Overall, serum S100B positively-correlates with FBG/HbA1c in SPE patients. Serum S100B and FBG/HbA1c are independent risk factors, and their combination has high value on predicting adverse pregnancy outcomes of SPE patients.

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Fig. 1: Correlation between serum S100B levels and glucose metabolism indexes in SPE patients.
Fig. 2: Analysis of serum S100B levels and glucose metabolism indexes in SPE patients with adverse pregnancy outcomes.
Fig. 3: Value of serum S100B combined with glucose metabolism indexes on predicting adverse pregnancy outcomes of SPE patients.

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All the data generated or analyzed during this study are included in this published article.

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  1. Department of Gynaecology and Obstetrics, Zhangye Second People’s Hospital, Linsong West Street, Binhe New District, Ganzhou District, Zhangye City, 734000, Gansu Province, PR China

    Aiqin Yan

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Yan, A. Application value of serum S100B combined with glucose metabolism indexes in predicting adverse pregnancy outcomes of patients with severe preeclampsia. J Hum Hypertens 38, 232–237 (2024). https://doi.org/10.1038/s41371-023-00887-x

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