Cell biology

Definition

Cell biology is the discipline of biological sciences that studies the structure, physiology, growth, reproduction and death of cells. Research in cell biology uses microscopic and molecular tools and examines all cell types, from unicellular organisms such as protozoa to the specialised cells that consitutute multicellular organisms.

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Latest Research and Reviews

  • Research | | open

    The human congenital disorder Noonan Syndrome (NS) is caused by germ-line mutations that hyperactivate the RAS/ERK signalling pathway, and can feature pathologic cardiac enlargement. Here, the authors find that a complex cellular and molecular interplay involving a cytokine hierarchy underlies cardiac hypertrophy caused by a NS-associated Raf allele.

    • Jiani C. Yin
    • , Mathew J. Platt
    • , Xixi Tian
    • , Xue Wu
    • , Peter H. Backx
    • , Jeremy A. Simpson
    • , Toshiyuki Araki
    •  & Benjamin G. Neel
  • Research |

    Using confocal and lattice light sheet microscopy, the authors perform systems-level analysis of the organelle interactome in live cells, allowing them to visualize the frequency and locality of up to five-way interactions between different organelles.

    • Alex M. Valm
    • , Sarah Cohen
    • , Wesley R. Legant
    • , Justin Melunis
    • , Uri Hershberg
    • , Eric Wait
    • , Andrew R. Cohen
    • , Michael W. Davidson
    • , Eric Betzig
    •  & Jennifer Lippincott-Schwartz
  • Research | | open

    Tumor cell proliferation and migration, key drivers of metastasis, can be mechanistically coupled in matrix embedded human sarcoma and carcinoma cells through cell density via a synergistic, paracrine signaling mechanism between Interleukins 6/8. Inhibition of this mechanism significantly decreases metastasis in mouse xenograft models.

    • Hasini Jayatilaka
    • , Pranay Tyle
    • , Jonathan J. Chen
    • , Minsuk Kwak
    • , Julia Ju
    • , Hyun Ji Kim
    • , Jerry S. H. Lee
    • , Pei-Hsun Wu
    • , Daniele M. Gilkes
    • , Rong Fan
    •  & Denis Wirtz
  • Research |

    In human cell lines with mutant KRAS and loss of LKB1, CPS1 expression correlates inversely with LKB1 expression; silencing CPS1 in these cells induces DNA damage and cell death as a result of pyrimidine depletion rather than ammonia toxicity.

    • Jiyeon Kim
    • , Zeping Hu
    • , Ling Cai
    • , Kailong Li
    • , Eunhee Choi
    • , Brandon Faubert
    • , Divya Bezwada
    • , Jaime Rodriguez-Canales
    • , Pamela Villalobos
    • , Yu-Fen Lin
    • , Min Ni
    • , Kenneth E. Huffman
    • , Luc Girard
    • , Lauren A. Byers
    • , Keziban Unsal-Kacmaz
    • , Christopher G. Peña
    • , John V. Heymach
    • , Els Wauters
    • , Johan Vansteenkiste
    • , Diego H. Castrillon
    • , Benjamin P. C. Chen
    • , Ignacio Wistuba
    • , Diether Lambrechts
    • , Jian Xu
    • , John D. Minna
    •  & Ralph J. DeBerardinis
  • Research | | open

    IRE1? is an ER stress sensor, whose activity induces apoptosis. Here, the authors report that fortilin, a pro-survival factor, with yet unknown roles in ER stress, interacts with active IRE1?, inhibits both its kinase end RNase activities, and protects cells from apoptosis both in vitro and in vivo.

    • Decha Pinkaew
    • , Abhijnan Chattopadhyay
    • , Matthew D. King
    • , Preedakorn Chunhacha
    • , Zhihe Liu
    • , Heather L. Stevenson
    • , Yanjie Chen
    • , Patuma Sinthujaroen
    • , Owen M. McDougal
    •  & Ken Fujise
  • Reviews |

    Blood and lymphatic vessels have essential roles in physiology and disease. The endothelial cells that line these vessels specialize to fulfil the needs of the tissue that they pervade. Recent studies in animal models have provided insights into the mechanisms underlying vessel type- and organ-specific specialization, which is crucial for the understanding of several diseases.

    • Michael Potente
    •  & Taija Mäkinen

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