Cell biology

Definition

Cell biology is the discipline of biological sciences that studies the structure, physiology, growth, reproduction and death of cells. Research in cell biology uses microscopic and molecular tools and examines all cell types, from unicellular organisms such as protozoa to the specialised cells that consitutute multicellular organisms.

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Latest Research and Reviews

  • Reviews |

    Accumulation of misfolded protein in neurons is a common feature of many neurodegenerative diseases. In this Review, Hetz and Saxena discuss the latest advances in our understanding about the mechanisms by which protein misfolding causes neurodegeneration, and look at novel insights into the role of cellular responses to protein misfolding in synaptic function and in inflammatory and mechanical injury in the nervous system.

    • Claudio Hetz
    •  & Smita Saxena
  • Reviews |

    Cellular senescence is causally linked to ageing and has been implicated in a variety of age-related diseases. Here, van Deursen and colleagues review the characteristics of senescent cells and highlight evidence for a role of these cells in diseases, including cancer, atherosclerosis and osteoarthritis. Emerging strategies for therapeutically targeting senescent cells and the associated challenges are discussed.

    • Bennett G. Childs
    • , Martina Gluscevic
    • , Darren J. Baker
    • , Remi-Martin Laberge
    • , Dan Marquess
    • , Jamie Dananberg
    •  & Jan M. van Deursen
  • Research |

    Glucose starvation activates AMPK via an AMP/ADP-independent mechanism that involves fructose-1,6-bisphosphate and aldolase.

    • Chen-Song Zhang
    • , Simon A. Hawley
    • , Yue Zong
    • , Mengqi Li
    • , Zhichao Wang
    • , Alexander Gray
    • , Teng Ma
    • , Jiwen Cui
    • , Jin-Wei Feng
    • , Mingjiang Zhu
    • , Yu-Qing Wu
    • , Terytty Yang Li
    • , Zhiyun Ye
    • , Shu-Yong Lin
    • , Huiyong Yin
    • , Hai-Long Piao
    • , D. Grahame Hardie
    •  & Sheng-Cai Lin
  • Research |

    The cysteine protease CPR-4, a cathepsin B homologue, is identified as a radiation-induced bystander effect (RIBE) factor in nematodes in response to ultraviolet or ionizing radiation, and causes inhibition of cell death and increased embryonic lethality.

    • Yu Peng
    • , Man Zhang
    • , Lingjun Zheng
    • , Qian Liang
    • , Hanzeng Li
    • , Jeng-Ting Chen
    • , Hongyan Guo
    • , Sawako Yoshina
    • , Yu-Zen Chen
    • , Xiang Zhao
    • , Xiaoqi Wu
    • , Bin Liu
    • , Shohei Mitani
    • , Jau-Song Yu
    •  & Ding Xue

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