Ten years ago, the repulsive guidance molecules (RGMs), a family of three glycosylphosphatidylinositol–anchored glycoproteins, were identified as highly specific co-receptors of the bone morphogenetic proteins (BMPs). Newly reported crystal structures provide exciting insights into how RGM co-receptors may modulate BMP signaling.
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References
Weiss, A. & Attisano, L. Wiley Interdiscip. Rev. Dev. Biol. 2, 47–63 (2013).
Carreira, A.C., Alves, G.G., Zambuzzi, W.F., Sogayar, M.C. & Granjeiro, J.M. Arch. Biochem. Biophys. 561, 64–73 (2014).
Massagué, J. Nat. Rev. Mol. Cell Biol. 13, 616–630 (2012).
Nickel, J., Sebald, W., Groppe, J.C. & Mueller, T.D. Cytokine Growth Factor Rev. 20, 367–377 (2009).
Mueller, T.D. & Nickel, J. FEBS Lett. 586, 1846–1859 (2012).
Babitt, J.L. et al. J. Biol. Chem. 280, 29820–29827 (2005).
Samad, T.A. et al. J. Biol. Chem. 280, 14122–14129 (2005).
Corradini, E., Babitt, J.L. & Lin, H.Y. Cytokine Growth Factor Rev. 20, 389–398 (2009).
Severyn, C.J., Shinde, U. & Rotwein, P. Biochem. J. 422, 393–403 (2009).
Healey, E. et al. Nat. Struct. Mol. Biol. 22, 458–465 (2015).
Matsunaga, E. et al. Nat. Cell Biol. 6, 749–755 (2004).
Monnier, P.P. et al. Nature 419, 392–395 (2002).
Rajagopalan, S. et al. Nat. Cell Biol. 6, 756–762 (2004).
Conrad, S., Genth, H., Hofmann, F., Just, I. & Skutella, T. J. Biol. Chem. 282, 16423–16433 (2007).
Tassew, N.G. et al. Cell Reports 8, 1146–1159 (2014).
Scott, F.L. et al. Nature 457, 1019–1022 (2009).
Lin, L. et al. Blood Cells Mol. Dis. 40, 122–131 (2008).
Tassew, N.G., Charish, J., Seidah, N.G. & Monnier, P.P. Dev. Cell 22, 391–402 (2012).
Lin, L., Goldberg, Y.P. & Ganz, T. Blood 106, 2884–2889 (2005).
Keller, S., Nickel, J., Zhang, J.L., Sebald, W. & Mueller, T.D. Nat. Struct. Mol. Biol. 11, 481–488 (2004).
Hartung, A. et al. Mol. Cell. Biol. 26, 7791–7805 (2006).
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Mueller, T. RGM co-receptors add complexity to BMP signaling. Nat Struct Mol Biol 22, 439–440 (2015). https://doi.org/10.1038/nsmb.3037
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DOI: https://doi.org/10.1038/nsmb.3037
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