X-ray crystallography


X-ray crystallography is a technique that uses X-ray diffraction patterns to determine high-resolution, three-dimensional structures of molecules such as proteins, small organic molecules, and materials. The substance of interest must be in crystalline form, which typically requires testing various crystallization conditions.


Latest Research and Reviews

News and Comment

  • News and Views |

    New structures of the glucagon-like peptide-1 (GLP-1) and glucagon receptors in complex with peptide and nonpeptide ligands provide a comprehensive, detailed picture of the molecular mechanisms of action of family B GPCRs. This opens the door for true structure-based drug discovery aimed at both novel orthosteric and allosteric subsites of the receptors.

    • Thue W Schwartz
    •  & Thomas M Frimurer
  • News and Views |

    The envelope glycoprotein spike, the sole antigen on the Lassa virus (LASV) surface, constitutes the focal point of the host neutralizing immune response. A high-resolution structure of the trimeric LASV glycoprotein in an antibody-bound form illuminates the molecular architecture of the antigen and reveals the mode of action of the most abundant known class of Lassa-specific human neutralizing antibodies.

    • Antra Zeltina
    •  & Thomas A Bowden
  • News and Views |

    Notch signaling is an essential cell–cell communication pathway that influences numerous cell fate decisions during development. Structural and biochemical studies of a Notch–Jagged complex dramatically advance current understanding of ligand recognition, and reveal evidence of catch-bond behavior in the complex.

    • Stephen C Blacklow
  • News and Views |

    Enzymology and structural and functional characterization of some FAD-dependent monooxygenases provide insights into degradation of tetracycline antibiotics, but also show unexpected features of substrate recognition, reaction mechanism, and competitive inhibition.

    • Sonja Petkovic
    •  & Winfried Hinrichs