Data from a retrospective study indicate that survivors of testicular cancer whose treatment included abdominal radiotherapy have an increased risk of secondary pancreatic cancer that persisists for decades after their original diagnosis. Based on estimates of the dose of radiation to the pancreas received by 80 long-term (>5-year) testicular cancer survivors and 115 matched individuals, patients with previous testicular cancer have a 2.9-fold increased risk of pancreatic cancer that increases by 0.12 for each Gy of radiation delivered to the pancreas.
References
Hauptmann, M. et al. Increased pancreatic cancer risk following radiotherapy for testicular cancer. Br. J. Cancer http://dx.doi.org/10.1038/bjc.2016.272 (2016)
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Sidaway, P. Radiotherapy increases pancreatic cancer risk. Nat Rev Urol 13, 632 (2016). https://doi.org/10.1038/nrurol.2016.190
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DOI: https://doi.org/10.1038/nrurol.2016.190