Testicular cancer

Definition

Testicular cancer is a cancer that starts in the testis. The majority (95%) of testicular cancers are germ cell tumours. Treatment for testicular cancer is highly effective, with 5-year overall survival rates approaching 100% for localized disease.

Latest Research and Reviews

  • Research | | open

    Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

    • Jun Fang
    • , Jinping Jia
    • , Matthew Makowski
    • , Mai Xu
    • , Zhaoming Wang
    • , Tongwu Zhang
    • , Jason W. Hoskins
    • , Jiyeon Choi
    • , Younghun Han
    • , Mingfeng Zhang
    • , Janelle Thomas
    • , Michael Kovacs
    • , Irene Collins
    • , Marta Dzyadyk
    • , Abbey Thompson
    • , Maura O’Neill
    • , Sudipto Das
    • , Qi Lan
    • , Roelof Koster
    • , PanScan Consortium
    • , Federico Canzian
    • , Charles Kooperberg
    • , Zhaoming Wang
    • , Alan A Arslan
    • , Paige M Bracci
    • , Julie Buring
    • , Eric J Duell
    • , Steven Gallinger
    • , Eric J Jacobs
    • , Aruna Kamineni
    • , Stephen Van Den Eeden
    • , Alison P Klein
    • , Laurence N Kolonel
    • , Donghui Li
    • , Sara H Olson
    • , Harvey A Risch
    • , Howard D Sesso
    • , Kala Visvanathan
    • , Wei Zheng
    • , Demetrius Albanes
    • , Melissa A Austin
    • , Marie-Christine Boutron-Ruault
    • , H Bas Bueno-de-Mesquita
    • , Michelle Cotterchio
    • , J Michael Gaziano
    • , Edward L Giovannucci
    • , Michael Goggins
    • , Myron Gross
    • , Manal Hassan
    • , Kathy J Helzlsouer
    • , Elizabeth A Holly
    • , David J Hunter
    • , Mazda Jenab
    • , Rudolf Kaaks
    • , Timothy J Key
    • , Kay-Tee Khaw
    • , Vittorio Krogh
    • , Robert C Kurtz
    • , Andrea LaCroix
    • , Loic Le Marchand
    • , Satu Mannisto
    • , Alpa V Patel
    • , Petra H M Peeters
    • , Elio Riboli
    • , Xiao-Ou Shu
    • , Malin Sund
    • , Mark Thornquist
    • , Anne Tjønneland
    • , Geoffrey S Tobias
    • , Dimitrios Trichopoulos
    • , Jean Wactawski-Wende
    • , Herbert Yu
    • , Kai Yu
    • , Anne Zeleniuch-Jacquotte
    • , Robert Hoover
    • , Patricia Hartge
    • , Charles Fuchs
    • , Stephen J Chanock
    • , TRICL Consortium
    • , Victoria Stevens
    • , Demetrios Albanes
    • , Neil E Caporaso
    • , Paul Brennan
    • , James McKay
    • , Xifeng Wu
    • , Rayjean J Hung
    • , John R McLaughlin
    • , Heike Bickeboller
    • , Angela Risch
    • , Erich Wichmann
    • , Richard Houlston
    • , GenoMEL Consortium
    • , Graham Mann
    • , John Hopper
    • , Joanne Aitken
    • , Bruce Armstrong
    • , Graham Giles
    • , Elizabeth Holland
    • , Richard Kefford
    • , Anne Cust
    • , Jennifer H. Barrett
    • , Amaury Vaysse
    • , Coby Out
    • , Susana Puig
    • , Miriam Potrony
    • , Wilma Bergman
    • , Tadeusz Debniak
    • , Mark M. Iles
    • , Pascal W. T. C. Jansen
    • , Cristina Carrera
    • , Alisa M Goldstein
    • , Valerie Chaudru
    • , Marie-Francoise Avril
    • , Luc Thomas
    • , Veronica Hoiom
    • , Marinus van Praag
    • , Giorgi Landi
    • , Stuart Mac Gregor
    • , Nelleke Gruis
    • , Gemma Tell Marti
    • , Myriam Bossard
    • , Josep Malvehy
    • , Fabio Arcangeli
    • , Patricia Jeannin
    • , Christopher I. Amos
    • , Hans Vasen
    • , Grant Montgomery
    • , Mark Harland
    • , Florence Demenais
    • , Christian Ingvar
    • , Montse Mila
    • , Eva Wierzbicka
    • , Dominique Leroux
    • , Jeremie Nsengimana
    • , John Davies
    • , Lars A Akslen
    • , Virginia Andreotti
    • , Jo Gascoyne
    • , Bart Janssen
    • , Alon Scope
    • , Joan-AntonPuig Batille
    • , Srdjan Novakovic
    • , Brian M. Wolpin
    • , Jon Laye
    • , Peter Kraft
    • , Francoise Boitier
    • , Goran Jonsson
    • , Dyon Snels
    • , Hakan Olsson
    • , Nandita Mitra
    • , Paola Queirolo
    • , David Whiteman
    • , Sara Olson
    • , Bert Bakker
    • , Lorenze Pastorino
    • , Caroline Robert
    • , Juliette Randerson-Moor
    • , Celia Badenas
    • , Ake Borg
    • , William Bruno
    • , Marko Hocevar
    • , Katherine A. McGlynn
    • , Esther Azizi
    • , Ludovic Martin
    • , May Chan
    • , Thorkell Andresson
    • , Fabienne Lesueur
    • , Stephane Dalle
    • , Frederic Caux
    • , Jan Lubinski
    • , Irit Cohen-Manheim
    • , Han van der Rhee
    • , Julie Lang
    • , Eitan Freidman
    • , David Elder
    • , Per Helsing
    • , Eve Maubec
    • , Johan Hansson
    • , Orna Baron-Epel
    • , Barbara Peric
    • , Maria Teresa Landi
    • , Laufey T. Amundadottir
    • , Francesco Spagnolo
    • , Lieve Brochez
    • , Paula Aguilera
    • , Marianne Crijns
    • , Kari Nielsen
    • , Per Arne Andresen
    • , Kevin M. Brown
    • , Rianne Gerritsen
    • , Oliver Caron
    • , Dominique Stoppa-Lyonnet
    • , Rachael S. Stolzenberg-Solomon
    • , Peter A. Kanetsky
    • , Gloria M. Petersen
    • , Marcel Bekkenk
    • , Oliviier Dereure
    • , Petra Skerl
    • , Helen Schmid
    • , Julia A. Newton-Bishop
    • , Michiel Vermeulen
    • , Jan Nico Bouwes Bavinck
    • , Nicholas Martin
    • , Margaret A Tucker
    • , Hamida Mohamdi
    • , Christine Mateus
    • , Anita Schmidt Zander
    • , Nick Hayward
    • , Pablo Iglesias-Garcia
    • , Sally O'Shea
    • , Yael Laitman
    • , John C. Taylor
    • , David Duffy
    • , Alicia Barreiro
    • , Pol Gimenez Xavier
    • , Frans A van Nieuwpoort
    • , Pier Alberto Bertazzi
    • , Donato Calista
    • , Katherine L. Nathanson
    • , Xiaohong R Yang
    • , Rona Mackie
    • , Felix Pavlotsky
    • , Alison M. Dunning
    • , Paola Ghiorzo
    • , Ramon Pigem
    • , Nilanjan Chatterjee
    • , Daniel Gabriel
    • , D. Timothy Bishop
    • , Anders Molvern
    • , Mark Jenkins
    • , Paola Minghetti
    • , Brigitte Bressac-de Paillerets
    • , Michael Ming
    • , Jeanet ter Huurne
    • , Helge Rootwelt
    • , Nienke van der Stoep
    • , Nicole Kukutsch
    • , Giovanna Bianchi Scarra
    •  & Katja Harbst
  • Reviews |

    A need for improved serum diagnostic tests for testicular germ cell tumours (GCTs) exists owing to the unsatisfactory performance of currently used markers. In this Review, Murray and colleagues discuss the current serum diagnostic tests for testicular GCTs, including α-fetoprotein, human chorionic gonadotrophin and lactate dehydrogenase, and the future use of novel universal biomarkers such as microRNAs.

    • Matthew J. Murray
    • , Robert A. Huddart
    •  & Nicholas Coleman
  • Reviews |

    Care must be taken to limit the long-term risks of treatment of stage I testicular germ cell tumours (TGCT) as long-term survival is 99%. The management of this disease remains controversial as the options are to overtreat to prevent relapse, or to observe and treat only patients who experience disease relapse. In this Review, Chovanec and colleagues discuss the options for the management of clinical stage I TGCT.

    • Michal Chovanec
    • , Nasser Hanna
    • , K. Clint Cary
    • , Lawrence Einhorn
    •  & Costantine Albany
  • Reviews |

    The genomic landscape of testicular germ cell tumour (TGCT) risk is dominated by inherited genetic factors, which are highly polygenic in nature. Here, the authors discuss results from genome-wide association studies that have identified risk loci associated with TGCT risk. KITKITLG signalling is currently the major pathway that is implicated in TGCT formation.

    • Kevin Litchfield
    • , Max Levy
    • , Robert A. Huddart
    • , Janet Shipley
    •  & Clare Turnbull
  • Research | | open

    This genome-wide association study identifies four novel risk loci for testicular germ cell tumour, and provides functional correlation between a disease-associated variant and gene expression in patient samples for one of the identified loci.

    • Kevin Litchfield
    • , Amy Holroyd
    • , Amy Lloyd
    • , Peter Broderick
    • , Jérémie Nsengimana
    • , Rosalind Eeles
    • , Douglas F Easton
    • , Darshna Dudakia
    • , D. Timothy Bishop
    • , Alison Reid
    • , Robert A. Huddart
    • , Tom Grotmol
    • , Fredrik Wiklund
    • , Janet Shipley
    • , Richard S. Houlston
    •  & Clare Turnbull

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