Pancreatic cancer

Definition

Pancreatic cancer is a disease in which malignant cells originate in the pancreatic tissue. Cancer of the exocrine component of the pancreas (adenocarcinomas) represents the majority of pancreatic malignancies. Pancreatic cancer is generally characterized by a poor prognosis.

Latest Research and Reviews

  • Research |

    Michael Schatz, David Tuveson and colleagues analyze somatic noncoding alterations in 308 pancreatic ductal adenocarcinomas. They find recurrent noncoding regulatory mutations that correlate with differential expression of proximal genes and find that the strongest regulatory elements are more frequently mutated, suggesting a selective advantage for mutations in these regions.

    • Michael E Feigin
    • , Tyler Garvin
    • , Peter Bailey
    • , Nicola Waddell
    • , David K Chang
    • , David R Kelley
    • , Shimin Shuai
    • , Steven Gallinger
    • , John D McPherson
    • , Sean M Grimmond
    • , Ekta Khurana
    • , Lincoln D Stein
    • , Andrew V Biankin
    • , Michael C Schatz
    •  & David A Tuveson
    Nature Genetics 49, 825–833
  • Research | | open

    Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

    • Jun Fang
    • , Jinping Jia
    • , Matthew Makowski
    • , Mai Xu
    • , Zhaoming Wang
    • , Tongwu Zhang
    • , Jason W. Hoskins
    • , Jiyeon Choi
    • , Younghun Han
    • , Mingfeng Zhang
    • , Janelle Thomas
    • , Michael Kovacs
    • , Irene Collins
    • , Marta Dzyadyk
    • , Abbey Thompson
    • , Maura O’Neill
    • , Sudipto Das
    • , Qi Lan
    • , Roelof Koster
    • , PanScan Consortium
    • , Federico Canzian
    • , Charles Kooperberg
    • , Zhaoming Wang
    • , Alan A Arslan
    • , Paige M Bracci
    • , Julie Buring
    • , Eric J Duell
    • , Steven Gallinger
    • , Eric J Jacobs
    • , Aruna Kamineni
    • , Stephen Van Den Eeden
    • , Alison P Klein
    • , Laurence N Kolonel
    • , Donghui Li
    • , Sara H Olson
    • , Harvey A Risch
    • , Howard D Sesso
    • , Kala Visvanathan
    • , Wei Zheng
    • , Demetrius Albanes
    • , Melissa A Austin
    • , Marie-Christine Boutron-Ruault
    • , H Bas Bueno-de-Mesquita
    • , Michelle Cotterchio
    • , J Michael Gaziano
    • , Edward L Giovannucci
    • , Michael Goggins
    • , Myron Gross
    • , Manal Hassan
    • , Kathy J Helzlsouer
    • , Elizabeth A Holly
    • , David J Hunter
    • , Mazda Jenab
    • , Rudolf Kaaks
    • , Timothy J Key
    • , Kay-Tee Khaw
    • , Vittorio Krogh
    • , Robert C Kurtz
    • , Andrea LaCroix
    • , Loic Le Marchand
    • , Satu Mannisto
    • , Alpa V Patel
    • , Petra H M Peeters
    • , Elio Riboli
    • , Xiao-Ou Shu
    • , Malin Sund
    • , Mark Thornquist
    • , Anne Tjønneland
    • , Geoffrey S Tobias
    • , Dimitrios Trichopoulos
    • , Jean Wactawski-Wende
    • , Herbert Yu
    • , Kai Yu
    • , Anne Zeleniuch-Jacquotte
    • , Robert Hoover
    • , Patricia Hartge
    • , Charles Fuchs
    • , Stephen J Chanock
    • , TRICL Consortium
    • , Victoria Stevens
    • , Demetrios Albanes
    • , Neil E Caporaso
    • , Paul Brennan
    • , James McKay
    • , Xifeng Wu
    • , Rayjean J Hung
    • , John R McLaughlin
    • , Heike Bickeboller
    • , Angela Risch
    • , Erich Wichmann
    • , Richard Houlston
    • , GenoMEL Consortium
    • , Graham Mann
    • , John Hopper
    • , Joanne Aitken
    • , Bruce Armstrong
    • , Graham Giles
    • , Elizabeth Holland
    • , Richard Kefford
    • , Anne Cust
    • , Jennifer H. Barrett
    • , Amaury Vaysse
    • , Coby Out
    • , Susana Puig
    • , Miriam Potrony
    • , Wilma Bergman
    • , Tadeusz Debniak
    • , Mark M. Iles
    • , Pascal W. T. C. Jansen
    • , Cristina Carrera
    • , Alisa M Goldstein
    • , Valerie Chaudru
    • , Marie-Francoise Avril
    • , Luc Thomas
    • , Veronica Hoiom
    • , Marinus van Praag
    • , Giorgi Landi
    • , Stuart Mac Gregor
    • , Nelleke Gruis
    • , Gemma Tell Marti
    • , Myriam Bossard
    • , Josep Malvehy
    • , Fabio Arcangeli
    • , Patricia Jeannin
    • , Christopher I. Amos
    • , Hans Vasen
    • , Grant Montgomery
    • , Mark Harland
    • , Florence Demenais
    • , Christian Ingvar
    • , Montse Mila
    • , Eva Wierzbicka
    • , Dominique Leroux
    • , Jeremie Nsengimana
    • , John Davies
    • , Lars A Akslen
    • , Virginia Andreotti
    • , Jo Gascoyne
    • , Bart Janssen
    • , Alon Scope
    • , Joan-AntonPuig Batille
    • , Srdjan Novakovic
    • , Brian M. Wolpin
    • , Jon Laye
    • , Peter Kraft
    • , Francoise Boitier
    • , Goran Jonsson
    • , Dyon Snels
    • , Hakan Olsson
    • , Nandita Mitra
    • , Paola Queirolo
    • , David Whiteman
    • , Sara Olson
    • , Bert Bakker
    • , Lorenze Pastorino
    • , Caroline Robert
    • , Juliette Randerson-Moor
    • , Celia Badenas
    • , Ake Borg
    • , William Bruno
    • , Marko Hocevar
    • , Katherine A. McGlynn
    • , Esther Azizi
    • , Ludovic Martin
    • , May Chan
    • , Thorkell Andresson
    • , Fabienne Lesueur
    • , Stephane Dalle
    • , Frederic Caux
    • , Jan Lubinski
    • , Irit Cohen-Manheim
    • , Han van der Rhee
    • , Julie Lang
    • , Eitan Freidman
    • , David Elder
    • , Per Helsing
    • , Eve Maubec
    • , Johan Hansson
    • , Orna Baron-Epel
    • , Barbara Peric
    • , Maria Teresa Landi
    • , Laufey T. Amundadottir
    • , Francesco Spagnolo
    • , Lieve Brochez
    • , Paula Aguilera
    • , Marianne Crijns
    • , Kari Nielsen
    • , Per Arne Andresen
    • , Kevin M. Brown
    • , Rianne Gerritsen
    • , Oliver Caron
    • , Dominique Stoppa-Lyonnet
    • , Rachael S. Stolzenberg-Solomon
    • , Peter A. Kanetsky
    • , Gloria M. Petersen
    • , Marcel Bekkenk
    • , Oliviier Dereure
    • , Petra Skerl
    • , Helen Schmid
    • , Julia A. Newton-Bishop
    • , Michiel Vermeulen
    • , Jan Nico Bouwes Bavinck
    • , Nicholas Martin
    • , Margaret A Tucker
    • , Hamida Mohamdi
    • , Christine Mateus
    • , Anita Schmidt Zander
    • , Nick Hayward
    • , Pablo Iglesias-Garcia
    • , Sally O'Shea
    • , Yael Laitman
    • , John C. Taylor
    • , David Duffy
    • , Alicia Barreiro
    • , Pol Gimenez Xavier
    • , Frans A van Nieuwpoort
    • , Pier Alberto Bertazzi
    • , Donato Calista
    • , Katherine L. Nathanson
    • , Xiaohong R Yang
    • , Rona Mackie
    • , Felix Pavlotsky
    • , Alison M. Dunning
    • , Paola Ghiorzo
    • , Ramon Pigem
    • , Nilanjan Chatterjee
    • , Daniel Gabriel
    • , D. Timothy Bishop
    • , Anders Molvern
    • , Mark Jenkins
    • , Paola Minghetti
    • , Brigitte Bressac-de Paillerets
    • , Michael Ming
    • , Jeanet ter Huurne
    • , Helge Rootwelt
    • , Nienke van der Stoep
    • , Nicole Kukutsch
    • , Giovanna Bianchi Scarra
    •  & Katja Harbst
  • Research | | open

    The functional significance of T-cell infiltration in pancreatic ductal adenocarcinoma in relation to desmoplastic stroma is unclear. Here the authors develop a method to spatially resolve tumour stroma composition and find that spatial T-cell infiltration correlates with patient prognosis regardless of desmoplasia.

    • Julienne L. Carstens
    • , Pedro Correa de Sampaio
    • , Dalu Yang
    • , Souptik Barua
    • , Huamin Wang
    • , Arvind Rao
    • , James P. Allison
    • , Valerie S. LeBleu
    •  & Raghu Kalluri

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