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Bladder cancer

Photodynamic diagnosis can improve surgical outcome

Nature Reviews Urology volume 7, pages 598–599 (2010)Cite this article

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Blue-light cystoscopy is a method of photodynamic diagnosis (PDD) used in the bladder which offers an opportunity to improve the quality of the endoscopic diagnosis and treatment of bladder cancer by enhancing the color contrast between tumor and non-tumor tissue. Introduced in Germany1 nearly 20 years ago, a substantial body of evidence, including a recent paper by Geavlete et al.,2 suggests that PDD markedly improves the completeness of the initial resection in transurethral endoscopic surgery.

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References

  1. Kriegmair, M. et al. Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence. J. Urol. 155, 105–110 (1996).

    Article  CAS  PubMed  Google Scholar 

  2. Geavlete, B., Jecu, M., Multescu, R., Georgescu, D. & Geavlete P. HAL blue-light cystoscopy in high-risk nonmuscle-invasive bladder cancer—re-TURBT recurrence rates in a prospective, randomized study. Urology 76, 664–669 (2010).

    Article  PubMed  Google Scholar 

  3. Babjuk, M. et al. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder. Eur. Urol. 54, 303–314 (2008).

    Article  PubMed  Google Scholar 

  4. Ray, E. R. et al. Hexylaminolevulinate photodynamic diagnosis for multifocal recurrent non-muscleinvasive bladder cancer. J. Endourol. 23, 983–988 (2009).

    Article  PubMed  Google Scholar 

  5. Stenzl, A. S. et al. Hexvix fluorescence cystoscopy improves detection and resection of papillary bladder cancer and reduces early recurrence: a multicentre prospective randomized study). Eur. Urol. Suppl. 8, 373 (2009).

    Article  Google Scholar 

  6. Thomas, K. & O'Brien, T. S. Blue sky thinking about blue light cystoscopy. BJU Int. 104, 887–890 (2009).

    Article  PubMed  Google Scholar 

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  1. Urology Center, Guys Hospital, Great Maze Pond, SE1 9RT, London, UK

    Tim O'Brien & Kay Thomas

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  1. Tim O'Brien
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  2. Kay Thomas
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Correspondence to Tim O'Brien.

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Competing interests

T. O'Brien and K. Thomas declare an association with the following company: GE Healthcare (speakers bureau/honoraria). T. O'Brien declares an association with the following company: Photocure (speakers bureau and grant/research support).

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O'Brien, T., Thomas, K. Photodynamic diagnosis can improve surgical outcome. Nat Rev Urol 7, 598–599 (2010). https://doi.org/10.1038/nrurol.2010.183

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