In patients with knee osteoarthritis and low vitamin D levels, monthly treatment with oral vitamin D3 (50,000 IU; n = 209) or placebo (n = 204) for 2 years did not lead to significant between-group differences in MRI-measured cartilage volume loss or knee pain score. The results do not support the use of vitamin D3 supplementation to prevent pain or cartilage loss in knee OA.
References
Jin, X. et al. Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: a randomized clinical trial. JAMA 315, 1005–1013 (2016)
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Onuora, S. Vitamin D not effective for knee OA. Nat Rev Rheumatol 12, 252 (2016). https://doi.org/10.1038/nrrheum.2016.47
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DOI: https://doi.org/10.1038/nrrheum.2016.47
