New criteria have been proposed to enable a rapid diagnosis of cryopyrin-associated periodic syndromes (CAPS) in children and adults. Will these diagnostic criteria advance the management of autoinflammatory syndromes, or will physicians now think of zebras rather than horses when they hear hoofbeats?
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Acknowledgements
The authors thank H. Wittkowski and D. Holzinger (both in the Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany) for analyses, literature research and help with writing the manuscript. They also thank E. Lainka, U. Neudorf (both at Children's Hospital, University Duisburg-Essen, Essen, Germany) and T. Niehues (HELIOS Klinikum Krefeld, Krefeld, Germany) for valuable input from the German AID registry.
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C.H. has received honoraria for consulting and lectures from Novartis and has received research support from Pfizer. D.F. has received honoraria for consulting and lectures from Chugai-Roche, Novartis, Pfizer and Sobi, and has received research support from Novartis and Pfizer.
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Hinze, C., Foell, D. New diagnostic criteria for CAPS — turning horses into zebras?. Nat Rev Rheumatol 13, 7–8 (2017). https://doi.org/10.1038/nrrheum.2016.201
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DOI: https://doi.org/10.1038/nrrheum.2016.201
