Autoantibodies against end products of lipid peroxidation have unexpected effects on atherosclerosis in systemic lupus erythematosus (SLE). The discovery of their effects could lead to new theories about the role of the adaptive immune system in SLE.
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Acknowledgements
The authors are supported by NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) grants R01AR063754-01A1 (M.M.) and K01-AR-059095 (B.S.).
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McMahon, M., Skaggs, B. Do IgM antibodies protect against atherosclerosis in SLE?. Nat Rev Rheumatol 12, 442–444 (2016). https://doi.org/10.1038/nrrheum.2016.108
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DOI: https://doi.org/10.1038/nrrheum.2016.108
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