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Autoimmunity

Ro60-associated RNA takes its toll on disease pathogenesis

Nature Reviews Rheumatology volume 12, pages 136–138 (2016)Cite this article

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A new study attributes the pathogenicity of anti-Ro60 autoantibodies and type I interferon in systemic lupus erythematosus and Sjögren syndrome to Alu retroelements, but is this RNA the complete story?

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Figure 1: Model for anti-Ro60 autoantibody-mediated tissue injury in SLE, Sjögren syndrome and neonatal lupus.

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Acknowledgements

The authors' work is supported by the Department of Health, Australian Government, National Health and Medical Research Council (NHMRC) grants 595989 (J.H.R.) and 1041900 (T.P.G.).

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Authors and Affiliations

  1. Immunology Division, Garvan Institute of Medical Research, Immunogenomics Laboratory, 384 Victoria Street, Darlinghurst, NSW 2010, Australia

    Joanne H. Reed

  2. Department of Immunology, Flinders Medical Centre and SA Pathology, Bedford Drive, Bedford Park, SA 5042, Australia

    Tom P. Gordon

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  1. Joanne H. Reed
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Correspondence to Joanne H. Reed.

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The authors declare no competing financial interests.

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Reed, J., Gordon, T. Ro60-associated RNA takes its toll on disease pathogenesis. Nat Rev Rheumatol 12, 136–138 (2016). https://doi.org/10.1038/nrrheum.2015.148

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