Pre-natal glucocorticoid exposure affected the mental health of children (n = 37) at 8 years of age, compared with controls (n = 185), but effects were not significant by 16 years of age, according to the analysis of a longitudinal cohort. The propensity-scored method and mixed effects model using data collected by teachers and parents indicates that general psychiatric disturbance and inattention (symptoms of attention deficit hyperactivity disorder) are associated with exposure to low or infrequent doses of pre-natal glucocorticoids.
References
Khalife, N. et al. Prenatal glucocorticoid treatment and later mental health in children and adolescents. PLoS ONE 10.1371/journal.pone.0081394
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Pre-natal glucocorticoids and childhood mental health. Nat Rev Rheumatol 10, 2 (2014). https://doi.org/10.1038/nrrheum.2013.194
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DOI: https://doi.org/10.1038/nrrheum.2013.194