Steroid hormones

Definition

Steroid hormones are a group of hormones, derived from cholesterol, from the class of compounds known as steroids. They are secreted by the adrenal cortex, testes and ovaries, and by the placenta during pregnancy. On the basis of their receptors, steroid hormones have been classified into five groups: glucocorticoids, mineralocorticoids, androgens, oestrogens and progestogens.

Latest Research and Reviews

  • Reviews |

    Steroid hormone receptors are well known to regulate various aspects of animal physiology by acting as transcriptional regulators in the nucleus. However, it is now evident that these receptors can also be targeted to extranuclear locations (such as the plasma membrane), where they instigate rapid signals that contribute to steroid-mediated cellular responses.

    • Ellis R. Levin
    •  & Stephen R. Hammes
  • Reviews |

    Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Here, Azziz et al. describe the current state of knowledge regarding the epidemiology, pathophysiology, diagnosis, management and future investigational directions of the disorder.

    • Ricardo Azziz
    • , Enrico Carmina
    • , ZiJiang Chen
    • , Andrea Dunaif
    • , Joop S. E. Laven
    • , Richard S. Legro
    • , Daria Lizneva
    • , Barbara Natterson-Horowtiz
    • , Helena J. Teede
    •  & Bulent O. Yildiz
  • Research | | open

    How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx43, mediated by unliganded progesterone receptor A.

    • Lubna Nadeem
    • , Oksana Shynlova
    • , Elzbieta Matysiak-Zablocki
    • , Sam Mesiano
    • , Xuesen Dong
    •  & Stephen Lye
  • Research | | open

    Males are less susceptible to autoimmune diseases due to immunomodulatory effects of androgen. Here the authors show that androgen receptor upregulates Aire and Aire-dependent transcription in the thymic epithelium, and that Aire is required for androgen-mediated suppression of experimental autoimmune encephalitis.

    • Meng-Lei Zhu
    • , Pearl Bakhru
    • , Bridget Conley
    • , Jennifer S. Nelson
    • , Meghan Free
    • , Aaron Martin
    • , Joshua Starmer
    • , Elizabeth M. Wilson
    •  & Maureen A. Su
  • Research | | open

    Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as regulators of lysophosphatidic acid signalling.

    • Willem-Jan Keune
    • , Jens Hausmann
    • , Ruth Bolier
    • , Dagmar Tolenaars
    • , Andreas Kremer
    • , Tatjana Heidebrecht
    • , Robbie P. Joosten
    • , Manjula Sunkara
    • , Andrew J. Morris
    • , Elisa Matas-Rico
    • , Wouter H. Moolenaar
    • , Ronald P. Oude Elferink
    •  & Anastassis Perrakis

News and Comment