Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Diagnosis

Severity scoring system for paediatric FMF

Nature Reviews Rheumatology volume 8, pages 309–310 (2012)Cite this article

Subjects

Severity scoring systems for adult familial Mediterranean fever (FMF) are established and used as important clinical and analytical tools in disease management and research. A recent paper highlights the need for a paediatric FMF severity measure. How should such a score be built and what challenges might be faced?

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Ozen, S. et al. Disease severity in children and adolescents with familial Mediterranean fever: a comparative study to explore environmental effects on a monogenic disease. Ann. Rheum. Dis. 68, 246–248 (2009).

    Article  CAS  Google Scholar 

  2. Kalkan, G. et al. Evaluation of the current disease severity scores in paediatric FMF: is it necessary to develop a new one? Rheumatology (Oxford) 51, 743–748 (2012).

    Article  CAS  Google Scholar 

  3. Pras, E. et al. Clinical differences between North African and Iraqi Jews with familial Mediterranean fever. Am. J. Med. Genet. 75, 216–219 (1998).

    Article  CAS  Google Scholar 

  4. Mor, A. et al. Evaluation of disease severity in familial Mediterranean fever. Semin. Arthritis Rheum. 35, 57–64 (2005).

    Article  Google Scholar 

  5. Cakar, N. et al. Familial Mediterranean fever (FMF)-associated amyloidosis in childhood. Clinical features, course and outcome. Clin. Exp. Rheumatol. 19 (Suppl. 24), S63–S67 (2001).

    CAS  PubMed  Google Scholar 

  6. Dusunsel, R. et al. Genotype-phenotype correlation in children with familial Mediterranean fever in a Turkish population. Pediatr. Int. 50, 208–212 (2008).

    Article  CAS  Google Scholar 

  7. Yalcinkaya, F., Ozcakar, Z. B., Tanyildiz, M. & Elhan, A. H. Familial Mediterranean fever in small children in Turkey. Clin. Exp. Rheumatol. 29 (Suppl. 67), S87–S90 (2011).

    PubMed  Google Scholar 

  8. Padeh, S. et al. Familial Mediterranean fever in children presenting with attacks of fever alone. J. Rheumatol. 37, 865–869 (2010).

    Article  Google Scholar 

  9. Padeh, S. et al. Familial Mediterranean Fever in the first two years of life: a unique phenotype of disease in evolution. J. Pediatr. 156, 985–989 (2010).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Sheba Medical Centre, Tel-Hashomer, 52621, Ramat-Gan, Israel

    Avi Livneh

Authors
  1. Avi Livneh
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Livneh, A. Severity scoring system for paediatric FMF. Nat Rev Rheumatol 8, 309–310 (2012). https://doi.org/10.1038/nrrheum.2012.54

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2012.54

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing