Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Connective tissue diseases

Predicting death in SSc: planning and cooperation are needed

Nature Reviews Rheumatology volume 7, pages 628–630 (2011)Cite this article

Subjects

Systemic sclerosis is associated with a high level of patient mortality. A promising prognostic model that could enable more effective management and improve survival was recently validated; however, the results demonstrate that choosing the best cohorts for development and validation of predictors of mortality is essential.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Steen, V. D. & Medsger, T. A. Changes in causes of death in systemic sclerosis, 1972–2002. Ann. Rheum. Dis. 66, 940–944 (2007).

    Article  Google Scholar 

  2. Al-Dhaher, F. F., Pope, J. E. & Ouimet, J. M. Determinants of morbidity and mortality of systemic sclerosis in Canada. Semin. Arthritis Rheum. 39, 269–277 (2010).

    Article  Google Scholar 

  3. Nihtyanova, S. et al. Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: a retrospective cohort study. QJM 103, 109–115 (2010).

    Article  CAS  Google Scholar 

  4. Fransen, J. et al. Clinical prediction of 5-year survival in systemic sclerosis: validation of a simple prognostic model in EUSTAR centres. Ann. Rheum. Dis. 70, 1788–1792 (2011).

    Article  CAS  Google Scholar 

  5. Bryan, C., Howard, Y., Brennan, P., Black, C. & Silman, A. Survival following the onset of scleroderma: results from a retrospective inception cohort study of the UK patient population. Br. J. Rheumatol. 35, 1122–1126 (1996).

    Article  CAS  Google Scholar 

  6. Wilson, P. W. et al. Prediction of coronary heart disease using risk factor categories. Circulation 97, 1837–1847 (1998).

    Article  CAS  Google Scholar 

  7. Wasson, J. H., Sox, H. C., Neff, R. K. & Goldman, L. Clinical prediction rules. Applications and methodological standards. N. Engl. J. Med. 313, 793–799 (1985).

    Article  CAS  Google Scholar 

  8. Laupacis, A., Sekar, N. & Stiell, I. G. Clinical prediction rules. A review and suggested modifications of methodological standards. JAMA 277, 488–494 (1997).

    Article  CAS  Google Scholar 

  9. Toll, D. B., Janssen, K. J., Vergouwe, Y. & Moons, K. G. Validation, updating and impact of clinical prediction rules: a review. J. Clin. Epidemiol. 61, 1085–1094 (2008).

    Article  CAS  Google Scholar 

  10. Altman, D. G. & Royston, P. What do we mean by validating a prognostic model? Stat. Med. 19, 453–473 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Rheumatology and Clinical Immunology, S700 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, 15261, PA, USA

    Robyn T. Domsic & Thomas A. Medsger Jr

Authors
  1. Robyn T. Domsic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas A. Medsger Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas A. Medsger Jr.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Domsic, R., Medsger, T. Predicting death in SSc: planning and cooperation are needed. Nat Rev Rheumatol 7, 628–630 (2011). https://doi.org/10.1038/nrrheum.2011.152

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2011.152

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing