A 6-year follow-up study of the ADVANCE trial participants reports that intensive glycaemic control is renoprotective—but does not reduce mortality—in patients with type 2 diabetes mellitus. By contrast, a post hoc analysis of the ACCORD trial suggests that intensive glycaemic control might increase mortality in patients with diabetic nephropathy.
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de Borst, M., Navis, G. Risks of strict glycaemic control in diabetic nephropathy. Nat Rev Nephrol 11, 5–6 (2015). https://doi.org/10.1038/nrneph.2014.209
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DOI: https://doi.org/10.1038/nrneph.2014.209