Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Transplantation

An end to bone disease after renal transplantation?

Surprising new randomized trial data showed no clinically relevant decrease in bone mineral density at various skeletal sites 12 months after kidney transplantation in patients receiving baseline calcitriol and calcium therapy as well as ibandronate or placebo. These data raise important questions regarding strategies to prevent bone loss after renal transplantation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Julian, B. A. et al. Rapid loss of vertebral mineral density after renal transplantation. N. Engl. J. Med. 325, 544–550 (1991).

    Article  CAS  Google Scholar 

  2. Brandenburg, V. M., Westenfeld, R. & Ketteler, M. The fate of bone after renal transplantation. J. Nephrol. 17, 190–204 (2004).

    PubMed  Google Scholar 

  3. Palmer, S. C., McGregor, D. O. & Strippoli, G. F. Interventions for preventing bone disease in kidney transplant recipients. Cochrane Database Syst. Rev. Issue 3. Art. No.: CD005015 http://dx.doi.org/10.1002/14651858.CD005015.pub3.

  4. Kalantar-Zadeh, K., Molnar, M. Z., Kovesdy, C. P., Mucsi, I. & Bunnapradist, S. Management of mineral and bone disorder after kidney transplantation. Curr. Opin. Nephrol. Hypertens. 21, 389–403 (2012).

    Article  CAS  Google Scholar 

  5. Smerud, K. T. et al. A 1-year randomized, double-blind, placebo-controlled study of intravenous ibandronate on bone loss following renal transplantation. Am. J. Transplant. http://dx.doi.org/10.1111/j.1600-6143201204233.x.

  6. Kidney Disease: Improving Global Outcomes (KDIGO) CKD–MBD Work Group. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder (CKD-MBD). Kidney Int. Suppl. 113, S1–S130 (2009).

  7. Coco, M. et al. Effect of risedronate on bone in renal transplant recipients. J. Am. Soc. Nephrol. 23, 1426–1437 (2012).

    Article  CAS  Google Scholar 

  8. Grotz, W. et al. Effect of ibandronate on bone loss and renal function after kidney transplantation. J. Am. Soc. Nephrol. 12, 1530–1537 (2001).

    CAS  PubMed  Google Scholar 

  9. De Sévaux, R. G., Hoitsma, A. J., Corstens, F. H. & Wetzels, J. F. Treatment with vitamin D and calcium reduces bone loss after renal transplantation: a randomized study. J. Am. Soc. Nephrol. 13, 1608–1614 (2002).

    Article  Google Scholar 

  10. Mainra, R. & Elder, G. J. Individualized therapy to prevent bone mineral density loss after kidney and kidney–pancreas transplantation. Clin. J. Am. Soc. Nephrol. 5, 117–124 (2010).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vincent M. Brandenburg.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brandenburg, V., Floege, J. An end to bone disease after renal transplantation?. Nat Rev Nephrol 9, 5–6 (2013). https://doi.org/10.1038/nrneph.2012.245

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2012.245

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing