Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Paediatrics

Paediatric CRRT and ECMO: fluid overload is not the only issue

Nature Reviews Nephrology volume 8, pages 565–566 (2012)Cite this article

Subjects

Current dogma suggests that fluid overload—when associated with acute kidney injury (AKI)—is an independent risk factor for death. Although the volume status of the patient is important, there are other predictors of morbidity, mortality and the need for renal replacement therapy in patients with AKI.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Selewski, D. T. et al. Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy. Crit. Care Med. http://dx.doi.org/10.1097/CCM.0b013e318258ff01.

  2. Lane, P. H., Mauer, S. M., Blazar, B. R., Ramsay, N. K. & Kashtan, C. E. Outcome of dialysis for acute renal failure in pediatric bone marrow transplant patients. Bone Marrow Transplant. 13, 613–617 (1994).

    CAS  PubMed  Google Scholar 

  3. Goldstein, S. L. et al. Outcome in children receiving continuous venovenous hemofiltration. Pediatrics 107, 1309–1312 (2001).

    Article  CAS  Google Scholar 

  4. Foland, J. A. et al. Fluid overload before continuous hemofiltration and survival in critically ill children: a retrospective analysis. Crit. Care Med. 32, 1771–1776 (2004).

    Article  Google Scholar 

  5. Gillespie, R. S., Seidel, K. & Symons, J. M. Effect of fluid overload and dose of replacement fluid on survival in hemofiltration. Pediatr. Nephrol. 19, 94–99 (2004).

    Google Scholar 

  6. Goldstein, S. L. et al. Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy. Kidney Int. 67, 653–658 (2005).

    Article  Google Scholar 

  7. Symons, J. M. et al. Continuous renal replacement therapy in children up to 10 kg. Am. J. Kidney Dis. 41, 984–989 (2003).

    Article  Google Scholar 

  8. Bunchman, T. E. et al. Pediatric acute renal failure: outcome by modality and disease. Pediatr. Nephrol. 16, 1067–1071 (2001).

    Article  CAS  Google Scholar 

  9. Devarajan, P. Biomarkers for early detection of acute kidney injury. Curr. Opin. Pediatr. 23, 194–200 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Children's Hospital of Richmond, Virginia Commonwealth University School of Medicine, 1112 East Clay Street, Richmond, 23298, VA, USA

    Timothy E. Bunchman

Authors
  1. Timothy E. Bunchman
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares an association with the following company: Gambro Healthcare (Speaker Bureau).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bunchman, T. Paediatric CRRT and ECMO: fluid overload is not the only issue. Nat Rev Nephrol 8, 565–566 (2012). https://doi.org/10.1038/nrneph.2012.193

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2012.193

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing