Glucocorticoid use for >6 months reportedly does not improve outcomes and increases infection risk in patients with anti-neutrophil cytoplasmic autoantibody (ANCA) disease. Among 147 patients with ANCA disease, duration of glucocorticoid therapy did not influence time to relapse, relapse-free survival, risk of death or risk of end-stage renal disease, but use of these drugs for >6 months was associated with an increased risk of infection.
ORIGINAL RESEARCH PAPER
McGregor, J. G. et al. Glucocorticoids and relapse and infection rates in anti–neutrophil cytoplasmic antibody disease. Clin. J. Am. Soc. Nephrol. doi:10.2215/CJN.05610611
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Glucocorticoid use and infection risk. Nat Rev Nephrol 8, 63 (2012). https://doi.org/10.1038/nrneph.2011.206
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DOI: https://doi.org/10.1038/nrneph.2011.206
