Orchestrating sleep-wake functions in the brain. Hajak, G. & Geisler, P. Nature Medicine February (2003) A News and Views article on the regulation of arousal by a feedback loop involving hypocretin and glutamate.

Interneurons take charge of brain networks. Moser, E. I. Nature 20 February (2003) A News and Views article on the role of hippocampal interneurons in controlling brain network dynamics during memory processes.

Signal dispersal and transduction through the endocytic pathway. González-Gaitán, M. Nature Reviews Molecular Cell Biology March (2003) This review discusses recent evidence that, in addition to internalizing receptors during cell signalling, the endocytic pathway also has a role in the secretion and dispersal of ligands.

Cox-2 inhibitors. Flower, R. J. Nature Reviews Drug Discovery March (2003) A Case History review on the development of one of the world's best-selling families of anti-inflammatory drugs.

A new role for an old kinase: CK2 and the circadian clock (News and Views). Blau, J. Nature Neuroscience March (2003)

Neuroblastoma: biological insights into a clinical enigma. Brodeur, G. M. Nature Reviews Cancer March (2003) Neuroblastoma is a tumour of the postganglionic sympathetic nervous system and is the most common solid tumour in childhood. This review describes recent advances in understanding the biology and genetics of neuroblastomas, and how this approach might influence the development of therapies.

Receptor and Ion Channel Trafficking. von Zastrow, M. Nature Cell Biology March (2003) M. von Zastrow reviews this book by Stephen J. Moss and Jeremy Henley.

A Life Shaken: My Encounter with Parkinson's Disease. Dunnett, S. B. Nature Medicine February (2003) S. B. Dunnett reviews the book of the same name written by Joel Havemann.

Intelligence tests predict brain response to demanding task events (News and Views). Duncan, J. Nature Neuroscience March (2003)

A framework for consciousness. Crick, F. & Koch, C. Nature Neuroscience February (2003) In the past, many investigations into consciousness have paid remarkably little attention to the structure and function of neuronal circuits. In this Commentary, the authors highlight the importance of studying the behaviour of small groups of neurons to further our understanding of the neural correlates of consciousness.