Hepatocellular carcinoma is associated with HCV infection but the underlying interplay between virus and tumour remains to be elucidated. Now, Harouaka et al. report that in patients with HCV-related cirrhosis, HCV replication is restricted within liver tissue originating from hepatocellular carcinoma, with an associated increase in the diversity and complexity of the HCV quasispecies.
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Holmes, J., Chung, R. HCV compartmentalization in HCC: driver, passenger or both?. Nat Rev Gastroenterol Hepatol 13, 254–256 (2016). https://doi.org/10.1038/nrgastro.2016.46
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DOI: https://doi.org/10.1038/nrgastro.2016.46
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