Improved methods are needed to dynamically image gut behaviour to assess whether neuromuscular degenerative disease is present. So-called nanonaps (soluble nanoformulated naphthalocyanines) have been developed for oral administration to pass through the intestines and provide high contrast for visualizing bowel motion on photoacoustic imaging. Moreover, radiotracer labelling of these nanoparticles facilitates multimodal detection using PET.
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The author would like to acknowledge grant support from the NIH R01 CA142750, U54 CA163059.
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Joshi, B., Wang, T. Dynamic imaging of gut function—allowing the blind to see. Nat Rev Gastroenterol Hepatol 11, 584–586 (2014). https://doi.org/10.1038/nrgastro.2014.149
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DOI: https://doi.org/10.1038/nrgastro.2014.149
