Recent reports suggest that molecular therapies targeting ANGPTL3 and its encoded protein angiopoietin-like protein 3 have clinical potential comparable to therapies targeting PCSK9 and its encoded protein proprotein convertase subtilisin/kexin type 9. By mainly affecting triglyceride-rich lipoproteins, ANGPTL3 inhibition might prove complementary to LDL cholesterol lowering with PCSK9 blockade.
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S.K. serves on a scientific advisory board for Regeneron Genetics Center, New York, USA, and has received consulting fees from Ionis Pharmaceuticals, California, USA. K.M. declares no competing interests.
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Musunuru, K., Kathiresan, S. Is ANGPTL3 the next PCSK9?. Nat Rev Endocrinol 13, 503–504 (2017). https://doi.org/10.1038/nrendo.2017.88
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DOI: https://doi.org/10.1038/nrendo.2017.88
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