Intensive control of blood glucose levels in patients with type 1 diabetes mellitus (T1DM) has long-term effects on kidney function. In the DCCT trial, patients with T1DM were randomly assigned to undergo intensive glycaemic treatment or conventional treatment; 1,375 patients subsequently took part in the EDIC study and were instructed in intensive glycaemic management while receiving treatment at their usual health-care provider. After 18 years of follow-up, the risks of developing microalbuminuria and macroalbuminuria were 45% and 61% reduced, and the risk of glomerular filtration rate <50 ml/min/1.73 m2 was 44% reduced, in patients who underwent intensive treatment during the DCCT.
References
de Boer, I. H. et al. Effect of intensive diabetes treatment on albuminuria in type 1 diabetes: long-term follow-up of the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications study. Lancet Diabetes Endocrinol. 10.1016/S2213-8587(14)70155-X
Rights and permissions
About this article
Cite this article
Long-term effects of intensive glycaemic control in T1DM. Nat Rev Endocrinol 10, 578 (2014). https://doi.org/10.1038/nrendo.2014.135
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2014.135