B cells have a key role in the regulation of immunity. Using gene expression studies of activated B cells, Shen et al. identified interleukin 35 (IL-35) as a new mediator of B cell-mediated immune regulation. Mice with B cells that did not express IL-35 were unable to recover from experimental autoimmune encephalomyelitis, and had improved resistance to infection with Salmonella enterica, which was mediated in part by an increased function of B cells as antigen-presenting cells. So IL-35 could be a putative new target for modulating immune function.
References
Shen, P. et al. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature http://dx.doi.org/10.1038/nature12979 (2014)
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Harrison, C. IL-35: a new player in B cell activity. Nat Rev Drug Discov 13, 258 (2014). https://doi.org/10.1038/nrd4299
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DOI: https://doi.org/10.1038/nrd4299
