Signal transducer and activator of transcription 3 (STAT3) exists in two main isoforms: STAT3α and STAT3β. STAT3β is generated by alternative splicing, and its overexpression can induce apoptosis and inhibit tumour growth. This study used phosphorodiamidate morpholino oligomers to redirect STAT3 alternative splicing from STAT3α to STAT3β. This splicing switch was associated with a reduced viability of cancer cells and tumour regression in a xenograft model, highlighting that redirection of alternative splicing could be a novel approach for cancer therapy.
ORIGINAL RESEARCH PAPER
Zammarchi, F. et al. Antitumorigenic potential of STAT3 alternative splicing modulation. Proc. Natl Acad. Sci. USA 108, 17779–17784 (2011)
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Harrison, C. Redirecting alternative splicing. Nat Rev Drug Discov 10, 902 (2011). https://doi.org/10.1038/nrd3619
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DOI: https://doi.org/10.1038/nrd3619
