In the PRomPT trial presented at the ESC Congress 2015, 126 patients with a large myocardial infarction were randomly assigned to receive dual-site biventricular pacing or single-site left ventricular pacing from an implanted cardiac resynchronization therapy–defibrillator, or not to have a device implanted. After 18 months of follow-up, the increase in left ventricular end-diastolic volume compared with baseline was not significantly different in the two peri-infarct pacing groups combined (16.7 ± 30.5 ml) compared with in the control group (15.3 ± 28.6 ml; P = 0.92). The researchers conclude that “peri-infarct pacing did not prevent left ventricular remodelling or improve functional or clinical outcomes ... in patients with [a] large first myocardial infarction”.
References
Stone, G. W. et al. Peri-infarct zone pacing to prevent adverse left ventricular remodelling in patients with large myocardial infarction. Eur. Heart J. 10.1093/eurheartj/ehv436
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No benefit of peri-infarct pacing after myocardial infarction. Nat Rev Cardiol 12, 622 (2015). https://doi.org/10.1038/nrcardio.2015.147
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DOI: https://doi.org/10.1038/nrcardio.2015.147