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Stem cells

Bone-marrow-derived cells and heart failure—the debate goes on

The therapeutic efficacy of bone-marrow-derived cells in patients with acute or chronic myocardial infarction has been a matter of intense debate. Three new clinical trials—the Swiss-AMI, CELLWAVE, and C-CURE studies—unfortunately do not resolve the controversy in the field of cell therapy for the damaged heart.

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Figure 1: Several cell types have been implemented clinically to promote myocardial regeneration.

References

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Correspondence to Piero Anversa.

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Leri, A., Anversa, P. Bone-marrow-derived cells and heart failure—the debate goes on. Nat Rev Cardiol 10, 372–373 (2013). https://doi.org/10.1038/nrcardio.2013.81

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