Deng et al. investigated whether signal transducer and activator of transcription 3 (STAT3), an oncogenic mediator of chemokine signalling, affects premetastatic niche formation. Activation of sphingosine 1-phosphate receptor 1 (S1PR1) causes persistent activation of STAT3, and the injection into mice of conditioned medium from tumour cells that overexpress S1PR1 induced premetastatic niche formation and STAT3 phosphorylation in the lung. Stat3 or S1pr1 ablation in myeloid cells prevented the formation of lung metastases, indicating that STAT3 activation at premetastatic sites promotes metastasis.
ORIGINAL RESEARCH PAPER
Deng, J. et al. S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell 21, 642–654 (2012)Article
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Alderton, G. STAT3 promotes premetastatic niche formation. Nat Rev Cancer 12, 453 (2012). https://doi.org/10.1038/nrc3313
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DOI: https://doi.org/10.1038/nrc3313
