Chromosomal translocations can promote cancers by eliciting the expression of fusion genes with oncogenic activity. The identification of translocations affecting RAF genes in prostate and gastric cancers and melanoma provides compelling evidence for the key role of RAF signaling in a subset of these cancers and suggests possible new avenues for personalized cancer therapy (pages 793–798).
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McMahon, M. RAF translocations expand cancer targets. Nat Med 16, 749–750 (2010). https://doi.org/10.1038/nm0710-749
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DOI: https://doi.org/10.1038/nm0710-749