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TORmented macrophages spontaneously form granulomas

Nature Immunology volume 18, pages 252–253 (2017)Cite this article

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Elevated signaling via the metabolic checkpoint kinase mTORC1 in macrophages stimulates spontaneous granuloma formation in mice and is associated with the progression of sarcoidosis in humans.

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Figure 1: Dysregulated mTORC1 signaling in macrophages promotes granulomatous inflammation.

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Authors and Affiliations

  1. Department of Medicine, Antonio J. Pagán and Lalita Ramakrishnan are in the Molecular Immunity Unit, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, UK.,

    Antonio J Pagán & Lalita Ramakrishnan

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  1. Antonio J Pagán
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  2. Lalita Ramakrishnan
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Correspondence to Antonio J Pagán or Lalita Ramakrishnan.

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Pagán, A., Ramakrishnan, L. TORmented macrophages spontaneously form granulomas. Nat Immunol 18, 252–253 (2017). https://doi.org/10.1038/ni.3689

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