Chronic inflammation

Definition

Chronic inflammation refers to a prolonged inflammatory response that involves a progressive change in the type of cells present at the site of inflammation. It is characterized by the simultaneous destruction and repair of the tissue from the inflammatory process. It can follow an acute form of inflammation or be a prolonged low-grade form.

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Latest Research and Reviews

News and Comment

  • News and Views |

    Using interleukin (IL)-9-deficient mice, Rauber and colleagues unveil a crucial role for group 2 innate lymphoid cells (ILC2s) in the resolution phase of arthritic inflammation, opening up new therapeutic avenues for chronic inflammatory disease.

    • Ben Roediger
    •  & Wolfgang Weninger
    Nature Medicine 23, 914–916
  • Comments and Opinion |

    Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues.

    • Mihai G Netea
    • , Frances Balkwill
    • , Michel Chonchol
    • , Fabio Cominelli
    • , Marc Y Donath
    • , Evangelos J Giamarellos-Bourboulis
    • , Douglas Golenbock
    • , Mark S Gresnigt
    • , Michael T Heneka
    • , Hal M Hoffman
    • , Richard Hotchkiss
    • , Leo A B Joosten
    • , Daniel L Kastner
    • , Martin Korte
    • , Eicke Latz
    • , Peter Libby
    • , Thomas Mandrup-Poulsen
    • , Alberto Mantovani
    • , Kingston H G Mills
    • , Kristen L Nowak
    • , Luke A O'Neill
    • , Peter Pickkers
    • , Tom van der Poll
    • , Paul M Ridker
    • , Joost Schalkwijk
    • , David A Schwartz
    • , Britta Siegmund
    • , Clifford J Steer
    • , Herbert Tilg
    • , Jos W M van der Meer
    • , Frank L van de Veerdonk
    •  & Charles A Dinarello
    Nature Immunology 18, 826–831
  • News and Views |

    A new study in mice suggests that a single drug, thymosin α1, may simultaneously rectify the impaired trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in cystic fibrosis (CF) and reduce inflammation, offering new hope for CF treatment.

    • André M Cantin
    •  & John W Hanrahan
    Nature Medicine 23, 536–538
  • News and Views |

    IRE1α is a stress sensor that is activated by a high-fat diet. In adipose-tissue macrophages, it serves as a major switch toward pro-inflammatory M1 polarization and thereby contributes to obesity and associated diseases.

    • Bojan Bujisic
    •  & Fabio Martinon
    Nature Immunology 18, 479–480