Antibodies bound to pathogens that invade cells are sensed in the cytosol by the receptor TRIM21, which triggers innate signaling that leads to protective immunity.
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References
Takeuchi, O. & Akira, S. Cell 140, 805–820 (2010).
McEwan, W.A. et al. Nat. Immunol. 14, 327–336 (2013).
Mallery, D.L. et al. Proc. Natl. Acad. Sci. USA 107, 19985–19990 (2010).
Burckhardt, C.J. et al. Cell Host Microbe 10, 105–117 (2011).
Hauler, F., Mallery, D.L., McEwan, W.A., Bidgood, S.R. & James, L.C. Proc. Natl. Acad. Sci. USA 109, 19733–19738 (2012).
Jiang, X. & Chen, Z.J. Nat. Rev. Immunol. 12, 35–48 (2012).
Champsaur, M. & Lanier, L.L. Immunol. Rev. 235, 267–285 (2010).
Fuchs, R. & Blaas, D. Rev. Med. Virol. 20, 281–297 (2010).
Su, A.I. et al. Proc. Natl. Acad. Sci. USA 101, 6062–6067 (2004).
Perreau, M., Pantaleo, G. & Kremer, E.J. J. Exp. Med. 205, 2717–2725 (2008).
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Geijtenbeek, T., Gringhuis, S. An inside job for antibodies: tagging pathogens for intracellular sensing. Nat Immunol 14, 309–311 (2013). https://doi.org/10.1038/ni.2574
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DOI: https://doi.org/10.1038/ni.2574
