A new study reports the whole-genome sequences of 21 Mycobacterium tuberculosis complex strains, selected to represent geographically diverse isolates. Comparative genomic analyses identify surprising conservation of epitopes recognized by human T cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Corbett, E.L. et al. Arch. Intern. Med. 163, 1009–1021 (2003).
Maartens, G. & Wilkinson, R.J. Lancet 370, 2030–2043 (2007).
Palmer, G.H., Bankhead, T. & Lukehart, S.A. Cell. Microbiol. 11, 1697–1705 (2009).
Comas, I. et al. Nat. Genet. 42, 498–503 (2010)
Gagneux, S. et al. Proc. Natl. Acad. Sci. USA 103, 2869–2873 (2006).
Plotkin, J.B., Dushoff, J. & Fraser, H.B. Nature 428, 942–945 (2004).
Kaufmann, S.H. Nat. Rev. Immunol. 1, 20–30 (2001).
Streeck, H. et al. PLoS Med. 5, e100 (2008).
Neumann-Haefelin, C. et al. J. Virol. 82, 3438–3451 (2008).
Vita, R. et al. Nucleic Acids Res. 38, D854–D862 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Sassetti, C., Rubin, E. Relics of selection in the mycobacterial genome. Nat Genet 42, 476–478 (2010). https://doi.org/10.1038/ng0610-476
Issue Date:
DOI: https://doi.org/10.1038/ng0610-476
