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Signal Transduction

Notch catches a Jagged edge

Nature Chemical Biology volume 13, pages 570–571 (2017)Cite this article

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Notch signaling is an essential cell–cell communication pathway that influences numerous cell fate decisions during development. Structural and biochemical studies of a Notch–Jagged complex dramatically advance current understanding of ligand recognition, and reveal evidence of catch-bond behavior in the complex.

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Figure 1: Notch–Jagged interaction schematic and structural features.

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Authors and Affiliations

  1. Stephen C. Blacklow is in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and the Department of Cancer Biology at the Dana–Farber Cancer Institute, Boston, Massachusetts, USA.,

    Stephen C Blacklow

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  1. Stephen C Blacklow
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Correspondence to Stephen C Blacklow.

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The author declares no competing financial interests.

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Blacklow, S. Notch catches a Jagged edge. Nat Chem Biol 13, 570–571 (2017). https://doi.org/10.1038/nchembio.2379

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