Chemical control of protein homeostasis and induction of protein destabilization are emerging therapeutic strategies. Two recent studies identify a set of sulfonamides that can modulate the CRL4DCAF15 E3 ligase complex to target the splicing factor RBM39 for proteasomal degradation.
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Winter, G. DCAFinating splicing. Nat Chem Biol 13, 575–576 (2017). https://doi.org/10.1038/nchembio.2378
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DOI: https://doi.org/10.1038/nchembio.2378