An artificial esterase with no known natural structural analogues has been formed via the homo-heptameric self-assembly of a designed peptide. This esterase represents the first report of a functional catalytic triad rationally engineered into a de novo protein framework.
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Makhlynets, O., Korendovych, I. Functional Frankensteins. Nature Chem 8, 823–824 (2016). https://doi.org/10.1038/nchem.2603
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DOI: https://doi.org/10.1038/nchem.2603
