Self-assembly

Definition

Self-assembly is the process by which an organized structure spontaneously forms from individual components, as a result of specific, local interactions among the components. When the constitutive components are molecules, the process is termed molecular self-assembly.

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Latest Research and Reviews

  • Research | | open

    Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to apoptosis.

    • M. T. Jeena
    • , L. Palanikumar
    • , Eun Min Go
    • , Inhye Kim
    • , Myoung Gyun Kang
    • , Seonik Lee
    • , Sooham Park
    • , Huyeon Choi
    • , Chaekyu Kim
    • , Seon-Mi Jin
    • , Sung Chul Bae
    • , Hyun Woo Rhee
    • , Eunji Lee
    • , Sang Kyu Kwak
    •  & Ja-Hyoung Ryu
  • Research | | open

    Designing and synthesizing protein mimetic molecules to form crystalline structures can be a challenge. Here the authors show lattice self-assembly of cyclodextrin complexes into a variety of capsid like structures, such as, lamellae, helical tubes and hollow rhombic dodecahedra.

    • Shenyu Yang
    • , Yun Yan
    • , Jianbin Huang
    • , Andrei V. Petukhov
    • , Loes M. J. Kroon-Batenburg
    • , Markus Drechsler
    • , Chengcheng Zhou
    • , Mei Tu
    • , Steve Granick
    •  & Lingxiang Jiang
  • Research | | open

    Several cell functions are based on the fuel-driven assembly and disassembly of supramolecular polymers under non-equilibrium conditions. Here, the authors show controlled formation and breaking of a supramolecular polymer by enzymatic phosphorylation and dephosphorylation of a building block by continuously adding ATP fuel and removing waste products.

    • Alessandro Sorrenti
    • , Jorge Leira-Iglesias
    • , Akihiro Sato
    •  & Thomas M. Hermans
  • Research | | open

    Container-molecules capable of recognizing charged species possess great potential as sensors, but are typically limited by their rigid frameworks. Here, Sun and co-workers design a family of adaptive metal-organic macrocycles that exhibit shape and size induced-fit transformations upon anion-binding.

    • Ting Zhang
    • , Li-Peng Zhou
    • , Xiao-Qing Guo
    • , Li-Xuan Cai
    •  & Qing-Fu Sun
  • Research | | open

    Natural complex systems are often constructed by sequential assembly but this is not readily available for synthetic systems. Here, the authors program the sequential self-assembly of DNA functionalized emulsions by altering the DNA grafted strands.

    • Yin Zhang
    • , Angus McMullen
    • , Lea-Laetitia Pontani
    • , Xiaojin He
    • , Ruojie Sha
    • , Nadrian C. Seeman
    • , Jasna Brujic
    •  & Paul M. Chaikin

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