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References
Hebbring, S.J. Immunology 141, 157–165 (2014).
Denny, J.C. et al. Nat. Biotechnol. 31, 1102–1110 (2013).
Ye, Z. et al. Eur. J. Hum. Genet. http://dx.doi.org/10.1038/ejhg.2014.123 (30 July 2014).
Novac, N. Trends Pharmacol. Sci. 34, 267–272 (2013).
Plenge, R.M., Scolnick, E.M. & Altshuler, D. Nat. Rev. Drug Discov. 12, 581–594 (2013).
Sanseau, P. et al. Nat. Biotechnol. 30, 317–320 (2012).
Okada, Y. et al. Nature 506, 376–381 (2014).
Power, A., Berger, A.C. & Ginsburg, G.S. J. Am. Med. Assoc. 311, 2063–2064 (2014).
Law, V. et al. Nucleic Acids Res. 42, D1091–D1097 (2014).
Cobanoglu, M.C., Oltvai, Z.N., Taylor, D.L. & Bahar, I. Bioinformatics 31, 131–133 (2015).
LaBute, M.X. et al. PLoS ONE 9, e106298 (2014).
Liu, X. et al. J. Cheminform. 6, 33 (2014).
Aronson, A.R. & Lang, F.M. J. Am. Med. Inform. Assoc. 17, 229–236 (2010).
A Catalog of Published Genome-Wide Association Studies. http://www.genome.gov/gwastudies. Accessed 1 February 2014.
Sun, X., Han, F., Yi, J., Hou, N. & Cao, Z. Mol. Med. Rep. 7, 1636–1640 (2013).
Wang, Z.Y. & Zhang, H.Y. Nat. Biotechnol. 31, 1080–1082 (2013).
Kilicoglu, H., Shin, D., Fiszman, M., Rosemblat, G. & Rindflesch, T.C. Bioinformatics 28, 3158–3160 (2012).
Griffith, M. et al. Nat. Methods 10, 1209–1210 (2013).
Acknowledgements
This project was supported in part by US National Center for Advancing Translational Sciences grant UL1TR000427 and National Library of Medicine grant 1K22LM011938. M.R.-M. was funded through philanthropic support of the Marshfield Clinic Research Foundation's “Dr. John Melski Endowed Physician Scientist” award granted to S.M.L. We thank J. Denny and colleagues for making the PheWAS catalog available online. We also thank D. Wall for project management and R. Stankowski for critical review, editing and comments.
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Supplementary Text and Figures
Supplementary Figures 1 and 2 (PDF 491 kb)
Supplementary Table 1
Complete list of drug-disease pairs including PheWAS association results, gene target, phenotype, candidate drug, significance category, number of supporting references from Medline abstracts and the Clinical Trial Registry, and overlap with GWAS results. (XLSX 4283 kb)
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Rastegar-Mojarad, M., Ye, Z., Kolesar, J. et al. Opportunities for drug repositioning from phenome-wide association studies. Nat Biotechnol 33, 342–345 (2015). https://doi.org/10.1038/nbt.3183
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DOI: https://doi.org/10.1038/nbt.3183
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